[HTML][HTML] c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease
MJ Yáñez, O Belbin, LD Estrada, N Leal… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Abstract Background Niemann-Pick type C (NPC) disease is characterized by lysosomal
accumulation of cholesterol. Interestingly, NPC patients' brains also show increased levels …
accumulation of cholesterol. Interestingly, NPC patients' brains also show increased levels …
[HTML][HTML] Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells
M Malnar, M Kosicek, A Lisica, M Posavec… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Cholesterol accumulation in Niemann–Pick type C disease (NPC) causes increased levels
of the amyloid-precursor-protein C-terminal fragments (APP-CTFs) and intracellular amyloid …
of the amyloid-precursor-protein C-terminal fragments (APP-CTFs) and intracellular amyloid …
APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease
Amyloid-β (Aβ) peptides originating from β-amyloid precursor protein (APP) are critical in
Alzheimer's disease (AD). Cellular cholesterol levels/distribution can regulate production …
Alzheimer's disease (AD). Cellular cholesterol levels/distribution can regulate production …
[HTML][HTML] Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase …
M Malnar, M Kosicek, S Mitterreiter… - … et Biophysica Acta (BBA …, 2010 - Elsevier
The link between cholesterol and Alzheimer's disease has recently been revealed in
Niemann–Pick type C disease. We found that NPC1−/− cells show decreased expression of …
Niemann–Pick type C disease. We found that NPC1−/− cells show decreased expression of …
Loss of amyloid precursor protein in a mouse model of Niemann–Pick type C disease exacerbates its phenotype and disrupts tau homeostasis
A Nunes, SNR Pressey, JD Cooper, S Soriano - Neurobiology of disease, 2011 - Elsevier
Niemann–Pick type C disease (NPC) is a lysosomal storage disorder which, at the cellular
level, shows amyloid Aβ and tau pathologies comparable to those seen in the AD brain …
level, shows amyloid Aβ and tau pathologies comparable to those seen in the AD brain …
GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells
M Kosicek, P Wunderlich, J Walter… - … and biophysical research …, 2014 - Elsevier
Alzheimer's disease (AD) and a rare inherited disorder of cholesterol transport, Niemann-
Pick type C (NPC) share several similarities including aberrant APP processing and …
Pick type C (NPC) share several similarities including aberrant APP processing and …
Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin
Abstract Niemann-Pick type C (NPC) disease, an autosomal recessive disorder caused
primarily by loss-of-function mutations in NPC1 gene, is characterized neuropathologically …
primarily by loss-of-function mutations in NPC1 gene, is characterized neuropathologically …
Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann‐Pick type C disease
Niemann‐Pick type C (NPC) disease is a fatal autosomal recessive disorder characterized
by the accumulation of free cholesterol and glycosphingolipids in the endosomal‐lysosomal …
by the accumulation of free cholesterol and glycosphingolipids in the endosomal‐lysosomal …
Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann‐Pick type C1‐deficient mouse brains
A Kodam, M Maulik, K Peake, A Amritraj, KS Vetrivel… - Glia, 2010 - Wiley Online Library
Abstract Niemann‐Pick type C (NPC) disease is an autosomal recessive neurodegenerative
disorder characterized by intracellular accumulation of cholesterol and glycosphingolipids in …
disorder characterized by intracellular accumulation of cholesterol and glycosphingolipids in …
Neuronal gene repression in Niemann–Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway
PS Contreras, M Gonzalez-Zuñiga… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Abstract Background Niemann–Pick type C (NPC) disease is a fatal neurodegenerative
disorder characterized by the accumulation of free cholesterol in lysosomes. There are …
disorder characterized by the accumulation of free cholesterol in lysosomes. There are …
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