Abstract Background Niemann-Pick type C (NPC) disease is characterized by lysosomal
accumulation of cholesterol. Interestingly, NPC patients' brains also show increased levels …

Cholesterol accumulation in Niemann–Pick type C disease (NPC) causes increased levels
of the amyloid-precursor-protein C-terminal fragments (APP-CTFs) and intracellular amyloid …

Amyloid-β (Aβ) peptides originating from β-amyloid precursor protein (APP) are critical in
Alzheimer's disease (AD). Cellular cholesterol levels/distribution can regulate production …

The link between cholesterol and Alzheimer's disease has recently been revealed in
Niemann–Pick type C disease. We found that NPC1−/− cells show decreased expression of …

Niemann–Pick type C disease (NPC) is a lysosomal storage disorder which, at the cellular
level, shows amyloid Aβ and tau pathologies comparable to those seen in the AD brain …

Alzheimer's disease (AD) and a rare inherited disorder of cholesterol transport, Niemann-
Pick type C (NPC) share several similarities including aberrant APP processing and …

Abstract Niemann-Pick type C (NPC) disease, an autosomal recessive disorder caused
primarily by loss-of-function mutations in NPC1 gene, is characterized neuropathologically …

Niemann‐Pick type C (NPC) disease is a fatal autosomal recessive disorder characterized
by the accumulation of free cholesterol and glycosphingolipids in the endosomal‐lysosomal …

Abstract Niemann‐Pick type C (NPC) disease is an autosomal recessive neurodegenerative
disorder characterized by intracellular accumulation of cholesterol and glycosphingolipids in …

Abstract Background Niemann–Pick type C (NPC) disease is a fatal neurodegenerative
disorder characterized by the accumulation of free cholesterol in lysosomes. There are …