We describe the opioid properties of a tridecapeptide, the sequence of which corresponds to
the NH2-terminal sequence of dynorphin, a novel porcine pituitary endorphin. It contains …

It is known that the opioid peptide dynorphin A has a broad distribution throughout the
neuraxis. Recent biochemical studies have extended the sequence of dynorphin A by 15 …

By the aid of radioimmunoassay for [Arg 6]-Leu-enkephalin, we have isolated a new opioid
octapeptide (PH-8P) from porcine hypothalamus, which released immunoreactive [Arg 6] …

The discovery in the 1970s of endogenous opioid peptides including the enkephalins, H-Tyr-
Gly-Gly-Phe-Met-OH ([Meplenkephalin)(1) and H-Tyr-Gly-Gly-Phe-Leu-OH ([Leus] …

Dynorphin was recently isolated from porcine pituitary extracts and shown to be the most
potent known opioid peptide. Antisera were prepared to synthetic dynorphin-(1–13), the …

Distribution of the potent opioid peptide dynorphin has been determined in pituitary gland
(pig, beef, rat), in the various regions of rat brain, and in rat spinal cord, by using a highly …

The remarkable feature of the opioid system is the complexity of its ligands and their
interactions with the μ-, δ-and k-binding sites. The three endogenous opioid precursors give …

The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary,
has been determined. It is (H) Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp …

A specific antiserum was prepared against dynorphin B, an endogenous opioid peptide
contained in a recently isolated 4,000-dalton dynorphin. The antiserum did not crossreact …

Dynorphin is a 17 amino acid opioid peptide which was originally isolated and characterized
from pig neurohypophysis and gut extracts1–3. It contains a leucine-enkephalin (Leu …