Factors that regulate leukocyte entry and spread through CNS parenchyma during different
types of CNS insults are incompletely understood. Reactive astrocytes have been implicated …

Astrocytes form borders (glia limitans) that separate neural from non-neural tissue along
perivascular spaces, meninges and tissue lesions in the CNS. Transgenic loss-of-function …

Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS)
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …

Astrocytes are crucial regulators of innate and adaptive immune responses in the injured
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …

During multiple sclerosis (MS), an inflammatory and neurodegenerative disease of the
central nervous system (CNS), symptoms, and outcomes are determined by the location of …

Astrocytes regulate fundamentally important functions to maintain central nervous system
(CNS) homeostasis. Altered astrocytic function is now recognized as a primary contributing …

Astrocytes respond to insult with a process of cellular activation known as reactive
astrogliosis. One of the key signals regulating this phenomenon is the transcription factor …

Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …

We have studied the initial innate immune response to focal necrotic injury on different sides
of the mouse blood-brain barrier by two-photon intravital microscopy. Transgenic mice in …