[HTML][HTML] How mRNA therapeutics are entering the monoclonal antibody field
L Van Hoecke, K Roose - Journal of Translational Medicine, 2019 - Springer
In 1975, Milstein and Köhler revolutionized the medical world with the development of the
hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies …
hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies …
[HTML][HTML] Advancements in mRNA encoded antibodies for passive immunotherapy
Monoclonal antibodies are the fastest growing therapeutic class in medicine today. They
hold great promise for a myriad of indications, including cancer, allergy, autoimmune and …
hold great promise for a myriad of indications, including cancer, allergy, autoimmune and …
[HTML][HTML] mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
YS Wang, M Kumari, GH Chen, MH Hong… - Journal of Biomedical …, 2023 - Springer
Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …
major challenge in realizing this drug class will promise to develop methods for safely …
[HTML][HTML] mRNA: a novel avenue to antibody therapy?
T Schlake, M Thran, K Fiedler, R Heidenreich… - Molecular Therapy, 2019 - cell.com
First attempts to use exogenous mRNA for protein expression in vivo were made more than
25 years ago. However, widespread appreciation of in vitro transcribed mRNA as a powerful …
25 years ago. However, widespread appreciation of in vitro transcribed mRNA as a powerful …
[HTML][HTML] The clinical progress of mRNA vaccines and immunotherapies
The emergency use authorizations (EUAs) of two mRNA-based severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of …
syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of …
A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs
KJ Kallen, A Theß - Therapeutic advances in vaccines, 2014 - journals.sagepub.com
Recent advances strongly suggest that mRNA rather than DNA will be the nucleotide basis
for a new class of vaccines and drugs. Therapeutic cancer vaccines against a variety of …
for a new class of vaccines and drugs. Therapeutic cancer vaccines against a variety of …
[HTML][HTML] Opportunities and challenges in the delivery of mRNA-based vaccines
In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
The challenge and prospect of mRNA therapeutics landscape
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …
in the pharmaceutical industry because they can be used for precise and individualized …
Recent advances in mRNA vaccine technology
Highlights•mRNA vaccines address many of the weaknesses of conventional vaccine
types.•Innovations in recent years revolutionized the applicability of mRNA vaccines.•mRNA …
types.•Innovations in recent years revolutionized the applicability of mRNA vaccines.•mRNA …
mRNA transcript therapy
D Weissman - Expert review of vaccines, 2015 - Taylor & Francis
mRNA is the central molecule of all forms of life. It is generally accepted that current life on
Earth descended from an RNA world. mRNA, after its first therapeutic description in 1992 …
Earth descended from an RNA world. mRNA, after its first therapeutic description in 1992 …