Ovarian cancer has the highest mortality rate of gynecologic malignancy. 18F-FDG positron
emission tomography (PET) adds an important superiority over traditional anatomic imaging …

Purpose The integrin αvβ3 and aminopeptidase N (APN/CD13) play vital roles in the tumor
angiogenesis process. They are highly expressed in a variety of tumor cells and proliferating …

Arginine-Glycine-Aspartate (RGD)-recognizing cell surface integrins are involved in tumor
growth, invasiveness/metastases, and angiogenesis, and are therefore an attractive …

Introduction: Previous studies have shown that peptides containing the asparagine-glycine-
arginine (NGR) sequence can specifically bind to CD13 (aminopeptidase N) receptor, a …

The aim of this study is to develop a novel Arg‐Gly‐Asp acid (RGD) and Ala‐Thr‐Trp‐Leu‐
Pro‐Pro‐Arg (ATWLPPR A7R) peptide‐containing ligand for 18F labeling as αvβ3 and …

Abstract Purpose Radiolabeled cyclic RGD (Arg-Gly-Asp) peptides have great potential for
the early tumor detection and noninvasive monitoring of tumor metastasis and therapeutic …

329 Objectives To identify and validate 18 F-RGD-K5, a click chemistry-derived RGD-
containing tracer for imaging integrin α v β 3 expression in vivo. Methods RGD-K5 binding …

Integrin αvβ3 and aminopeptidase N (APN, also known as CD13) are two important targets
involved in the regulation of angiogenesis, tumor proliferation, invasion, and metastasis. In …

18F-Galacto-RGD has been developed for PET of αvβ3 integrin expression, a receptor
involved in, for example, angiogenesis and metastasis. Our aim was to study the kinetics …

Integrin receptor αvβ3 and gastrin-releasing peptide receptor (GRPR) expression of tumors
could be detected using PET imaging with radiolabeled Arg-Gly-Asp (RGD) and the …