The mechanisms underlying the chronicity of autoimmune diseases of the central nervous
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …

In chronic inflammatory diseases of the central nervous system (CNS), immune cells
persisting behind the blood-brain barrier are supposed to promulgate local tissue …

The central nervous system (CNS) is classically viewed as immune-privileged; however,
recent advances highlight interactions between the peripheral immune system and CNS in …

Immune cell infiltration to the brain's territory was considered for decades to reflect a
pathological process in which immune cells attack the central nervous system (CNS); such a …

Epidemiological studies associate viral infections during childhood with the risk of
developing autoimmune disease during adulthood. However, the mechanistic link between …

Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …

T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …

The central nervous system (CNS) is under close surveillance by immune cells, which
mediate tissue homeostasis, protection, and repair. Conversely, in neuroinflammation …

Peripheral immune cell infiltration into the brain is a prominent feature in aging and various
neurodegenerative diseases such as Alzheimer's disease (AD). As AD progresses, CD8+ T …

The origin and function of CD20+ T cells are poorly understood. Here, we characterized
CD20+ T cells in mice and humans and investigated how they are affected by anti-CD20 …