Chronic stress triggers activation of the sympathetic nervous system and drives malignancy.
Using an immunodeficient murine system, we showed that chronic stress–induced …

Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor
relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive …

Numerous studies have found that chronic stress could promote tumor progression and this
may be related to inhibtion of immune system. Myeloid-derived suppressor cells (MDSCs) …

According to the 2020 data released by the International Agency for Research on Cancer,
breast cancer has surpassed lung cancer as the world's most newly diagnosed first-time …

The relationship between psychosocial factors and cancer has intrigued people for
centuries. In the last several decades there has been an expansion of mechanistic research …

Psychological stress is an emotion experienced when people are under mental pressure or
encounter unexpected problems. Extreme or repetitive stress increases the risk of …

Clinical studies suggest that stress-related biobehavioral factors can accelerate the
progression of hematopoietic cancers such as acute lymphoblastic leukemia (ALL), but it is …

Stress is an integral part of life. While acute responses to stress are generally regarded as
beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts …

Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role
in tumor progression. Macrophages in the tumor microenvironment (TME) polarized to M2 is …

Hypoxia is a feature of the microenvironment of many cancers and can trigger epithelial-
mesenchymal transition (EMT), a process by which cells acquire a more invasive phenotype …