Mechanisms of virologic failure in previously untreated HIV-infected patients from a trial of induction-maintenance therapy

D Descamps, P Flandre, V Calvez, G Peytavin… - Jama, 2000 - jamanetwork.com
ContextIn the Trilège trial, following induction with a zidovudine, lamivudine, and indinavir
regimen, human immunodeficiency virus (HIV) replication was less suppressed by 2-drug …

A randomized trial of three maintenance regimens given after three months of induction therapy with zidovudine, lamivudine, and indinavir in previously untreated HIV …

G Pialoux, F Raffi, F Brun-Vezinet… - … England Journal of …, 1998 - Mass Medical Soc
Background The long-term effectiveness of potent three-drug antiretroviral regimens for the
treatment of human immunodeficiency virus type 1 (HIV-1) infection is limited by problems …

Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens

DV Havlir, NS Hellmann, CJ Petropoulos, JM Whitcomb… - Jama, 2000 - jamanetwork.com
ContextLoss of viral suppression in patients infected with human immunodeficiency virus
(HIV), who are receiving potent antiretroviral therapy, has been attributed to outgrowth of …

Maintenance antiretroviral therapies in HIV-infected subjects with undetectable plasma HIV RNA after triple-drug therapy

DV Havlir, IC Marschner, MS Hirsch… - … England Journal of …, 1998 - Mass Medical Soc
Background Combination antiretroviral therapy with indinavir, zidovudine, and lamivudine
can suppress the level of human immunodeficiency virus (HIV) RNA in plasma below the …

Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection: 100-week follow-up

RM Gulick, JW Mellors, D Havlir, JJ Eron, C Gonzalez… - Jama, 1998 - jamanetwork.com
Context.—Combination antiretroviral therapy can markedly suppress human
immunodeficiency virus (HIV) replication but the duration of HIV suppression varies among …

Novel four-drug salvage treatment regimens after failure of a human immunodeficiency virus type 1 protease inhibitor-containing regimen: antiviral activity and …

SG Deeks, NS Hellmann, RM Grant… - The Journal of …, 1999 - academic.oup.com
Twenty human immunodeficiency virus—infected patients experiencing virologic failure of
an indinavir-or ritonavir-containing treatment regimen were evaluated in a prospective, open …

[HTML][HTML] Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection

RW Shafer, LM Smeaton, GK Robbins… - … England Journal of …, 2003 - Mass Medical Soc
Background It is unclear whether therapy for human immunodeficiency virus type 1 (HIV-1)
should be initiated with a four-drug or two sequential three-drug regimens. Methods In this …

Adherence to highly active antiretroviral therapy predicts virologic outcome at an inner-city human immunodeficiency virus clinic

JC McNabb, JW Ross, K Abriola… - Clinical Infectious …, 2001 - academic.oup.com
This study's hypothesis is that human immunodeficiency virus—infected patients in the inner
city (predominantly injection drug users and ethnic minorities) do not take highly active …

Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection

GK Robbins, V De Gruttola, RW Shafer… - … England Journal of …, 2003 - Mass Medical Soc
Background The optimal sequencing of antiretroviral regimens for the treatment of infection
with human immunodeficiency virus type 1 (HIV-1) is unknown. We compared several …

A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection

M Opravil, B Hirschel, A Lazzarin… - The Journal of …, 2002 - academic.oup.com
This randomized study evaluated the efficacy and tolerability of continued treatment with
protease inhibitor plus nucleoside-analogue combination regimens (n= 79) or a change to …