Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase
Y Wei, AY Peng, B Wang, L Ma, G Peng, Y Du… - European Journal of …, 2014 - Elsevier
A series of phosphorylated flavonoids were synthesized and investigated in vitro as
inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). The …
inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). The …
Inhibition of porcine liver carboxylesterase by phosphorylated flavonoids
We have recently synthesized a series of phosphorylated flavonoids and identified some of
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity …
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity …
A new synthesis of fully phosphorylated flavones as potent pancreatic cholesterol esterase inhibitors
G Peng, Y Du, Y Wei, J Tang, AY Peng… - Organic & Biomolecular …, 2011 - pubs.rsc.org
Five flavones possessing one to four phenolic groups were fully phosphorylated efficiently
and the obtained compounds showed excellent pancreatic cholesterol esterase (CEase) …
and the obtained compounds showed excellent pancreatic cholesterol esterase (CEase) …
Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase
B Li, B Zhou, H Lu, L Ma, AY Peng - European journal of medicinal …, 2010 - Elsevier
Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in
atherosclerosis and for the development of hypocholesterolemic agents, there are …
atherosclerosis and for the development of hypocholesterolemic agents, there are …
Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies
Abstract A library of forty 7, 8-benzoflavone derivatives was synthesized and evaluated for
their inhibitory potential against cholesterol esterase (CEase). Among all the synthesized …
their inhibitory potential against cholesterol esterase (CEase). Among all the synthesized …
Isocoumarin-based inhibitors of pancreatic cholesterol esterase
JJ Heynekamp, LA Hunsaker, TA Vander Jagt… - Bioorganic & medicinal …, 2008 - Elsevier
Pancreatic cholesterol esterase (CEase), which is secreted from the exocrine pancreas, is a
serine hydrolase that aids in the bile salt-dependent hydrolysis of dietary cholesteryl esters …
serine hydrolase that aids in the bile salt-dependent hydrolysis of dietary cholesteryl esters …
New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds
We present a new class of inhibitors of pancreatic cholesterol esterase (CEase) based on
'priviledged'5-benzylidenerhodanine and 5-benzylidene-2, 4-thiazolidinedione structural …
'priviledged'5-benzylidenerhodanine and 5-benzylidene-2, 4-thiazolidinedione structural …
[PDF][PDF] In vitro screening of the pancreatic cholesterol esterase inhibitory activity of some medicinal plants grown in Syria
BH Asmaa, N Ream - Int. J. Pharmacogn. Phytochem. Res, 2016 - researchgate.net
Hypercholesterolemia is implicated in atherosclerosis and associated cardiovascular
diseases. Plants have increasingly become attractive alternatives to prevent or treat these …
diseases. Plants have increasingly become attractive alternatives to prevent or treat these …
The inhibitory mechanism of pentacyclic triterpenoid acids on pancreatic lipase and cholesterol esterase
H Shen, J Wang, J Ao, L Ye, Y Shi, Y Liu, M Li, A Luo - Food Bioscience, 2023 - Elsevier
Inhibiting pancreatic Lipase (PL) and cholesterol esterase (CEase) can effectively control
blood triglycerides and cholesterol levels. The interaction characteristics of pentacyclic …
blood triglycerides and cholesterol levels. The interaction characteristics of pentacyclic …
Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1
J Zhang, QS Pan, XK Qian, XL Zhou… - Journal of Enzyme …, 2022 - Taylor & Francis
Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity.
Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of …
Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of …
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