The heterogeneity of fibroblasts in the murine and human lung during homeostasis and
disease is increasingly recognized. It remains unclear if the different phenotypes identified to …

Pulmonary mesenchymal cells are critical players in both the mouse and human during lung
development and disease states. They are increasingly recognized as highly …

Fibroblast heterogeneity has long been recognized in mouse and human lungs,
homeostasis, and disease states. However, there is no common consensus on fibroblast …

During lung development, the mesenchyme and epithelium are dependent on each other for
instructive morphogenic cues that direct proliferation, cellular differentiation and …

Lung fibroblasts are the major components in the connective tissue of the pulmonary
interstitium and play essential roles in the developing of postnatal lung, synthesizing the …

Fibroblasts substantially remodel extracellular matrix (ECM) in response to tissue injury and
generate fibrotic scars in chronic diseases. Recent studies have identified diverse fibroblast …

Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …

Fibroblasts are the primary cell type responsible for synthesis and remodeling of the
extracellular matrix (ECM) in response to injury. Targeting fibroblasts represents a promising …

Background and objectives: The heterogeneity of pulmonary fibroblasts, a critical aspect of
both murine and human models under physiological and pathological conditions, is well …

Rationale The lung mesenchyme gives rise to multiple distinct lineages of cells in the mature
respiratory system, including smooth muscle cells of the airway and vasculature. However, a …