In Vitro Antimalarial Activity and Drug Interactions of Fenofibric Acid
RPM Wong, TME Davis - Antimicrobial agents and chemotherapy, 2012 - Am Soc Microbiol
Plasmodium falciparum has developed resistance to most available treatments,
underscoring the need for novel antimalarial drugs. Fibrates are lipid-modifying agents used …
underscoring the need for novel antimalarial drugs. Fibrates are lipid-modifying agents used …
Diamidine Compounds: Selective Uptake and Targeting inPlasmodium falciparum
AMW Stead, PG Bray, IG Edwards, HP DeKoning… - Molecular …, 2001 - ASPET
Extensive drug resistance in Plasmodium falciparum emphasizes the urgent requirement for
novel antimalarial agents. Here we report potent antimalarial activity of a number of …
novel antimalarial agents. Here we report potent antimalarial activity of a number of …
In vitro antimalarial activity of flavonoid derivatives dehydrosilybin and 8-(1; 1)-DMA-kaempferide
F de Monbrison, M Maitrejean, C Latour, F Bugnazet… - Acta Tropica, 2006 - Elsevier
Multidrug-resistant Plasmodium falciparum strains are an increasing problem in endemic
areas and are partly responsible for the worsening malaria situation around the world. New …
areas and are partly responsible for the worsening malaria situation around the world. New …
Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate …
Y Talawanich, S Kamchonwongpaisan… - Acta tropica, 2015 - Elsevier
Interaction between antimalarial drugs is important in determining the outcome of
chemotherapy using drug combinations. Inhibitors of dihydrofolate reductase (DHFR) such …
chemotherapy using drug combinations. Inhibitors of dihydrofolate reductase (DHFR) such …
Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate—JPC2056—in cynomolgus monkeys using an in vivo–in vitro model
MD Edstein, BM Kotecka, AL Ager… - Journal of …, 2007 - academic.oup.com
Objectives To assess the antimalarial pharmacodynamics and pharmacokinetics of the
novel dihydrofolate reductase (DHFR) inhibitor, JPC2056 and its principal active metabolite …
novel dihydrofolate reductase (DHFR) inhibitor, JPC2056 and its principal active metabolite …
In vitro antimalarial interactions between mefloquine and cytochrome P450 inhibitors
R Wisedpanichkij, W Chaijaroenkul, P Sangsuwan… - Acta tropica, 2009 - Elsevier
The treatment and control of malaria is becoming increasingly difficult due to resistance of
Plasmodium falciparum strains resistance to commonly used antimalarials. Combination …
Plasmodium falciparum strains resistance to commonly used antimalarials. Combination …
Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant Plasmodium falciparum
L Gerena, GT Bass Sr, DE Kyle… - Antimicrobial agents …, 1992 - Am Soc Microbiol
The emergence of chloroquine resistance in Plasmodium falciparum has necessitated the
development of alternate strategies for chemotherapy and chemoprophylaxis. One approach …
development of alternate strategies for chemotherapy and chemoprophylaxis. One approach …
Ex Vivo Drug Susceptibility of Ferroquine against Chloroquine-Resistant Isolates of Plasmodium falciparum and P. vivax
ABSTRACT Ferroquine (FQ; SSR97193), a ferrocene-containing 4-aminoquinoline derivate,
has potent in vitro efficacy against chloroquine (CQ)-resistant Plasmodium falciparum and …
has potent in vitro efficacy against chloroquine (CQ)-resistant Plasmodium falciparum and …
Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of …
R Piedade, S Traub, A Bitter, AK Nüssler… - Antimicrobial Agents …, 2015 - Am Soc Microbiol
Malaria patients are frequently coinfected with HIV and mycobacteria causing tuberculosis,
which increases the use of coadministered drugs and thereby enhances the risk of …
which increases the use of coadministered drugs and thereby enhances the risk of …
Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P …
A series of 4-amino-7-chloroquinolines with dibenzylmethylamine (dibemethin) side chains
were shown to inhibit synthetic hemozoin formation. These compounds were equally active …
were shown to inhibit synthetic hemozoin formation. These compounds were equally active …