Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data

O Zohud, IM Lone, A Nashef… - Animal Models and …, 2023 - Wiley Online Library
Head and neck squamous cell cancer (HNSCC) is a leading global malignancy. Every year,
More than 830 000 people are diagnosed with HNSCC globally, with more than 430 000 …

Impact of genetic targets on therapy in head and neck squamous cell carcinoma

I Chaikhoutdinov, D Goldenberg - Impact of Genetic Targets on Cancer …, 2013 - Springer
Despite advances in surgical technique, radiation therapy and chemotherapy, the mortality
from head and neck squamous cell carcinoma (HNSCC) has not improved significantly …

Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies

I Tinhofer, D Braunholz, K Klinghammer - Cancers of the Head & Neck, 2020 - Springer
Comprehensive molecular characterization of head and neck squamous cell carcinoma
(HNSCC) has led to the identification of distinct molecular subgroups with fundamental …

[HTML][HTML] Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence

X Zhi, K Lamperska, P Golusinski, NJ Schork… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The squamous cell carcinomas represent about 90% of all head and neck cancers, ranking
the sixth most common human cancer. Approximately 450,000 of new cases of head and …

Mouse models for human head and neck squamous cell carcinomas

SL Lu, H Herrington, XJ Wang - Head & neck, 2006 - Wiley Online Library
Mouse models of human cancer play an important role in understanding the mechanisms of
carcinogenesis and have accelerated the search for finding new molecular targets for …

Genetically engineered mouse models of head and neck cancers

J Tasoulas, S Srivastava, X Xu, V Tarasova… - Oncogene, 2023 - nature.com
The head and neck region is one of the anatomic sites commonly afflicted by cancer, with~
1.5 million new diagnoses reported worldwide in 2020 alone. Remarkable progress has …

Molecular genetics and biology of head and neck squamous cell carcinoma: implications for diagnosis, prognosis and treatment

F Ganci, A Sacconi, V Manciocco… - Head and Neck …, 2012 - books.google.com
Head and neck cancers are different types of tumours found in the upper aero-digestive
tract. The vast majority of them (more than 90%) are squamous cell carcinomas (HNSCC) …

[HTML][HTML] Signaling networks of activated oncogenic and altered tumor suppressor genes in head and neck cancer

B Yan, R Vander Broek, AD Saleh… - … of carcinogenesis & …, 2013 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) arises from the upper aerodigestive
tract and is the six most common cancers worldwide. HNSCC is associated with high …

The molecular pathogenesis of head and neck squamous cell carcinoma

SM Rothenberg, LW Ellisen - The Journal of clinical …, 2012 - Am Soc Clin Investig
Squamous cell carcinoma of the head and neck (HNSCC) is a relatively common human
cancer characterized by high morbidity, high mortality, and few therapeutic options outside …

Genomic predictive model for recurrence and metastasis development in head and neck squamous cell carcinoma patients

IP Ribeiro, F Caramelo, L Esteves, J Menoita… - Scientific reports, 2017 - nature.com
The head and neck squamous cell carcinoma (HNSCC) population consists mainly of high-
risk for recurrence and locally advanced stage patients. Increased knowledge of the HNSCC …