Next‐generation vaccines: nanoparticle‐mediated DNA and mRNA delivery

W Ho, M Gao, F Li, Z Li, XQ Zhang… - Advanced healthcare …, 2021 - Wiley Online Library
Nucleic acid vaccines are a method of immunization aiming to elicit immune responses akin
to live attenuated vaccines. In this method, DNA or messenger RNA (mRNA) sequences are …

Nanotechnology-based mRNA vaccines

S Chen, X Huang, Y Xue, E Álvarez-Benedicto… - Nature Reviews …, 2023 - nature.com
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …

Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

C Rinoldi, SS Zargarian, P Nakielski, X Li… - Small …, 2021 - Wiley Online Library
In recent years, the main quest of science has been the pioneering of the groundbreaking
biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids …

Nanoparticles as adjuvants and nanodelivery systems for mRNA-based vaccines

IM Alfagih, B Aldosari, B AlQuadeib, A Almurshedi… - Pharmaceutics, 2020 - mdpi.com
Messenger RNA (mRNA)-based vaccines have shown promise against infectious diseases
and several types of cancer in the last two decades. Their promise can be attributed to their …

Engineered nanodelivery systems to improve DNA vaccine technologies

M Lim, AZM Badruddoza, J Firdous, M Azad, A Mannan… - Pharmaceutics, 2020 - mdpi.com
DNA vaccines offer a flexible and versatile platform to treat innumerable diseases due to the
ease of manipulating vaccine targets simply by altering the gene sequences encoded in the …

Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation

KA Afonin, MA Dobrovolskaia, W Ke… - Advanced drug delivery …, 2022 - Elsevier
With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now
poised for clinical translation supported by several examples of FDA-approved nucleic acid …

Nanoparticle-mediated cytoplasmic delivery of messenger RNA vaccines: challenges and future perspectives

Z Wu, T Li - Pharmaceutical Research, 2021 - Springer
The COVID-19 pandemic has left scientists and clinicians no choice but a race to find
solutions to save lives while controlling the rapid spreading. Messenger RNA (mRNA) …

Nanoparticles as adjuvants in vaccine delivery

A Garg, HK Dewangan - Critical Reviews™ in Therapeutic …, 2020 - dl.begellhouse.com
Nanotechnology provides an excellent platform for the development of a new generation of
vaccines. These are based on purified subunit proteins or polysaccharides, recombinant …

Microparticles and nanoparticles as delivery systems for DNA vaccines

Z Cui, RJ Mumper - Critical Reviews™ in Therapeutic Drug …, 2003 - dl.begellhouse.com
ABSTRACT DNA vaccines, also referred to as genetic vaccines, are generating significant
preclinical and clinical interest. It has been proven that the expression of an antigen or …

Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery

LM Mollé, CH Smyth, D Yuen… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Nucleic acid therapeutics can be used to control virtually every aspect of cell behavior and
therefore have significant potential to treat genetic disorders, infectious diseases, and …