The Apo (a) gene is the major determinant of variation in plasma Lp (a) levels in African Americans

V Mooser, D Scheer, SM Marcovina, J Wang… - The American Journal of …, 1997 - cell.com
The distributions of plasma lipoprotein (a), or Lp (a), levels differ significantly among ethnic
groups. Individuals of African descent have a two-to threefold higher mean plasma level of …

Comparative analysis of the apo (a) gene, apo (a) glycoprotein, and plasma concentrations of Lp (a) in three ethnic groups. Evidence for no common" null" allele at the …

A Gaw, E Boerwinkle, JC Cohen… - Journal of Clinical …, 1994 - ncbi.nlm.nih.gov
Distributions of plasma lipoprotein (a)(Lp [a]) concentrations exhibit marked interracial
differences. Apolipoprotein (a)(apo [a]), the unique constituent of Lp (a), is highly …

Genetic control of lipoprotein (a) concentrations is different in Africans and Caucasians

M Scholz, HG Kraft, A Lingenhel, R Delport… - European Journal of …, 1999 - nature.com
Abstract Lipoprotein (a)(Lp (a)) represents a quantitative trait in human plasma associated
with atherothrombotic disease. Large variation in the distribution of Lp (a) concentrations …

Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …

Serum distribution of lipoprotein (a) in African Americans and Nigerians: Potential evidence for a genotype‐environmental effect

CN Rotimi, RS Cooper, SM Marcovina… - Genetic …, 1997 - Wiley Online Library
Differences in lipoprotein (a)[Lp (a)] levels across populations have been described and
blacks are known to have higher Lp (a) values compared to whites. However, environmental …

Genetics of the quantitative Lp (a) lipoprotein trait: III. Contribution of Lp (a) glycoprotein phenotypes to normal lipid variation

E Boerwinkle, HJ Menzel, HG Kraft, G Utermann - Human genetics, 1989 - Springer
Summary Apolipoprotein (a)[apo (a)] is a large serum glycoprotein with several genetically
determined isoforms differing in their apparent molecular weight. We determined the effects …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …

Lipoprotein (a) in women twins: heritability and relationship to apolipoprotein (a) phenotypes.

MA Austin, C Sandholzer, JV Selby… - American journal of …, 1992 - ncbi.nlm.nih.gov
Lp (a) is a unique lipoprotein consisting of an LDL-like particle and a characteristic protein,
apo (a). Increased levels of Lp (a) constitute a risk factor for coronary heart disease …

Contribution of the apo [a] phenotype to plasma Lp [a] concentrations shows considerable ethnic variation.

M Helmhold, J Bigge, R Muche, J Mainoo, J Thiery… - Journal of lipid …, 1991 - Elsevier
Apolipoprotein [a] polymorphism has been investigated by sodium dodecyl sulfate
polyacrylamide (5.37%) gel electrophoresis and immunoblotting using a standardized …

Differences in Lp [a] concentrations and apo [a] polymorphs between black and white Americans

SM Marcovina, JJ Albers, E Wijsman, Z Zhang… - Journal of lipid …, 1996 - Elsevier
Lp [a] concentrations in nmol/L and apo [a] size isoforms, expressed in terms of the relative
number of apo [a] kringle 4 (K4) repeats, were determined in 3959 whites and blacks from …