The pharmacokinetics of mifepristone is characterized by rapid absorption, a long half-life of
25–30 h, and high micromolar serum concentrations following ingestion of doses of≥ 100 …

Mifepristone is a steroidal antiprogestin and antiglucocorticoid acting at the receptor level.
The aromatic dimethylaminophenyl side chain in position 11 of the steroid structure is …

Relatively low doses of the antiprogestin mifepristone (RU 486) have recently proven to be
efficient for a variety of possible clinical uses of the drug. However, the pharmacokinetics …

An emergency contraceptive method is used after coitus but before pregnancy occurs. The
use of emergency contraception is largely underutilized worldwide. Recently, treatment with …

While pregnant women have sought abortifacients for thousands of years, they had no
success at finding one that both worked and did not jeopardize their lives in the process. The …

The potentiality of mifepristone as an abortifacient and contraceptive drug along with its
pharmacokinetic parameters is reviewed. Mifepristone or RU486 acts as antagonist to …

Mifepristone is a progesterone and glucocorticoid receptor antagonist. Medical abortion with
mifepristone and prostaglandin has revolutionized the abortion process extending abortion …

Importance of the field: Mifepristone is a synthetic selective progesterone-receptor modulator
(SPRM) that is widely used around the globe in the field of reproductive medicine. At present …

Objectives To study the effect of antiprogestin on ovarian function and endometrial
development during the menstrual cycle and the possibility of using these compounds for …

Roussel Uclaf in partnership with the INSERM unit of Prof. EE Baulieu first discovered
mifepristone (RU486) as part of a large research program on steroidal compounds with …