Splicing cascades that alter gene products posttranscriptionally also affect expression
dynamics. We study a class of processes and associated distributions that emerge from …

Alternative splicing (AS) is a fundamental process during gene expression and has been
found to be ubiquitous in eukaryotes. However, how AS impacts gene expression levels …

The intrinsic stochasticity of gene expression can lead to large variability in protein levels for
genetically identical cells. Such variability in protein levels can arise from infrequent …

When messenger RNA splicing occurs co-transcriptionally, the potential for kinetic control
based on transcription dynamics is widely recognized. Indeed, perturbation studies have …

Genes with similar transcriptional activation kinetics can display very different temporal
mRNA profiles because of differences in transcription time, degradation rate, and RNA …

Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases
the complexity of gene expression programs, but is frequently altered in disease. Previous …

Transcriptional pulsing has been observed in both prokaryotes and eukaryotes and plays a
crucial role in cell-to-cell variability of protein and mRNA numbers. An important issue is how …

Recent analyses with high-resolution single-molecule experimental methods have shown
highly irregular and variable bursting of mRNA in a wide range of organisms. Noise in gene …

We explore a Markov model used in the analysis of gene expression, involving the bursty
production of pre-mRNA, its conversion to mature mRNA, and its consequent degradation …

There is accumulating evidence that, from bacteria to mammalian cells, messenger RNAs
(mRNAs) are produced in intermittent bursts–a much 'noisier'process than traditionally …