In humans, diabetes mellitus (DM) is considered a heterogeneous metabolic disorder.
Swine have been used as a model for many human conditions including type 1 (insulin …

For more than 50 years, investigators have unsuccessfully tried to recreate in experimental
animals the cardiovascular complications of diabetes seen in humans. In particular …

A weakness of many animal models of diabetes mellitus is the failure to use insulin therapy,
which typically results in severe body wasting. Data collected from such studies must be …

Diabetic patients typically have not only hyperglycemia but also dyslipidemia. Study of the
pathogenic components of the diabetic milieu and mechanisms of accelerated …

Genetic rodent models of type 2 diabetes are routinely utilized in studies of diabetes-related
cardiovascular disease; however, these models frequently exhibit abnormalities that are not …

The prevalence of diabetes throughout the world has increased dramatically over the recent
past, and the trend will continue for the foreseeable future. One of the major concerns …

The prevalence of diabetes mellitus, which currently affects 387 million people worldwide, is
permanently rising in both adults and adolescents. Despite numerous treatment options …

Diabetic cardiomyopathy increases the risk of heart failure in individuals with diabetes,
independently of co-existing coronary artery disease and hypertension. The underlying …

The non-obese diabetic (NOD) mouse spontaneously develops type 1 diabetes (T1D) and
has thus served as a model for understanding the genetic and immunological basis, and …

Animal models have been used extensively in diabetes research. Early studies used
pancreatectomised dogs to confirm the central role of the pancreas in glucose homeostasis …