CBFB break-apart FISH testing: an analysis of 1629 AML cases with a focus on atypical findings and their implications in clinical diagnosis and management
RK Yang, GA Toruner, W Wang, H Fang, GC Issa… - Cancers, 2021 - mdpi.com
Simple Summary The inv (16)/t (16; 16) AML is a disease that is considered relatively easy
and straightforward to be diagnosed in the clinical laboratories. Up to date, CBFB FISH …
and straightforward to be diagnosed in the clinical laboratories. Up to date, CBFB FISH …
Detection of a novel CBFB/MYH11 variant fusion transcript (K-type) showing partial insertion of exon 6 of CBFB gene using two commercially available multiplex RT …
TS Park, ST Lee, J Song, KA Lee, JH Lee, J Kim… - Cancer genetics and …, 2009 - Elsevier
We report on a 20-year-old man with acute myeloid leukemia (AML) showing a distinct novel
CBFB/MYH11 variant fusion transcript. Initial results of bone marrow, chromosome, and flow …
CBFB/MYH11 variant fusion transcript. Initial results of bone marrow, chromosome, and flow …
Fluorescence in situ hybridization identifies cryptic t (16; 16)(p13; q22) masked by del (16)(q22) in a case of AML-M4 Eo
SH Merchant, S Haines, B Hall, J Hozier… - The Journal of Molecular …, 2004 - Elsevier
We report a patient presenting with acute myeloid leukemia (AML)-M4 Eo, in whom
conventional cytogenetic analysis revealed a 46, XY, del (16)(q22) karyotype. Molecular …
conventional cytogenetic analysis revealed a 46, XY, del (16)(q22) karyotype. Molecular …
[HTML][HTML] Characteristics and Clinical Value of MYC, BCL2, and BCL6 Rearrangement Detected by Next-generation Sequencing in DLBCL
Y Zeng, R Wei, L Bao, T Xue, Y Qin… - The American Journal …, 2024 - journals.lww.com
Abstract MYC, BCL2, and BCL6 rearrangements are clinically important events of diffuse
large B-cell lymphoma (DLBCL). The ability and clinical value of targeted next-generation …
large B-cell lymphoma (DLBCL). The ability and clinical value of targeted next-generation …
Rare CBFB-MYH11 fusion transcripts in AML with inv (16)/t (16; 16) are associated with therapy-related AML M4eo, atypical cytomorphology, atypical …
S Schnittger, U Bacher, C Haferlach, W Kern… - Leukemia, 2007 - nature.com
The spectrum of CBFB-MYH11 fusion transcripts in acute myeloid leukemia (AML) M4eo
with inv (16)/t (16; 16) is heterogeneous. Approximately 85% show type A CBFB-MYH11 …
with inv (16)/t (16; 16) is heterogeneous. Approximately 85% show type A CBFB-MYH11 …
How to Improve Prognostication in Acute Myeloid Leukemia with CBFB-MYH11 Fusion Transcript: Focus on the Role of Molecular Measurable Residual Disease …
A Talami, F Bettelli, V Pioli, D Giusti, A Gilioli… - Biomedicines, 2021 - mdpi.com
Acute myeloid leukemia (AML) carrying inv (16)/t (16; 16), resulting in fusion transcript CBFB-
MYH11, belongs to the favorable-risk category. However, even if most patients obtain …
MYH11, belongs to the favorable-risk category. However, even if most patients obtain …
AML with CBFB–MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions
C Haferlach, F Dicker, A Kohlmann, S Schindela… - Leukemia, 2010 - nature.com
4 Carbuccia N, Trouplin V, Gelsi-Boyer V, Murati A, Rocquain J, Adelaide J et al. Mutual
exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. Leukemia …
exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. Leukemia …
[HTML][HTML] The whole is greater than the sum of its parts: Long‐read sequencing for solving clinical problems in haematology
C Bravo‐Perez, R Cifuentes‐Riquelme… - Journal of Cellular …, 2024 - ncbi.nlm.nih.gov
Structural variations (SVs) are common in haematological neoplasms. 1 Although most SVs
have canonical breakpoints, virtually all have atypical rearrangements that can be of difficult …
have canonical breakpoints, virtually all have atypical rearrangements that can be of difficult …
Quantification of CBFB-MYH11 fusion gene levels in paired peripheral blood and bone marrow samples by real-time PCR
N Boeckx, J De Roover, VHJ Van Der Velden… - Leukemia, 2005 - nature.com
Inv (16)(p13q22) and the related translocation t (16; 16)(p13; q22) generate a CBFB-MYH11
fusion gene transcript and are commonly found in acute myeloid leukemia (AML) M4Eo. 1 …
fusion gene transcript and are commonly found in acute myeloid leukemia (AML) M4Eo. 1 …
Incidental identification of inv (16)(p13. 1q22)/CBFB–MYH11 variant transcript in a patient with therapy-related acute myeloid leukemia by routine leukemia …
AE Quesada, R Luthra, E Jabbour… - Molecular …, 2021 - molecularcasestudies.cshlp.org
A 52-yr-old woman presented with therapy-related acute myeloid leukemia. A bone marrow
biopsy showed 21% blasts with a myeloid phenotype and no other notable features such as …
biopsy showed 21% blasts with a myeloid phenotype and no other notable features such as …