Iron participates in myriad processes necessary to sustain life. During the past decades,
great efforts have been made to understand iron regulation and function in health and …

Significance: Iron is an essential element required for sustaining a normal healthy life.
However, an excess amount of iron in the bloodstream and tissue generates toxic hydroxyl …

Iron deficiency and iron overload are the most prevalent and opposite forms of dysregulated
iron metabolism that affect approximately 30 percent of the world population, in particularly …

New insights into iron regulation and erythropoiesis : Current Opinion in Hematology New
insights into iron regulation and erythropoiesis : Current Opinion in Hematology Log in or …

Iron is irreplaceably required for animal and human cells as it provides the activity center for
a wide variety of essential enzymes needed for energy production, nucleic acid synthesis …

Iron is an ancient, essential and versatile transition metal found in almost all living
organisms on Earth. This fundamental trace element is used in the synthesis of heme and …

Despite its essential role in many biological processes, iron is toxic when in excess due to its
propensity to generate reactive oxygen species. To prevent diseases associated with iron …

The essential trace element iron regulates a wide range of biological processes in virtually
all living organisms. Because both iron deficiency and iron overload can lead to various …

Biological iron is necessary for vital functions and also potentially toxic to the organisms.
This dual effect raised the interest of many investigators to study the mechanisms controlling …

Inflammation, being a hallmark of many chronic diseases, including cancer, inflammatory
bowel disease, rheumatoid arthritis, and chronic kidney disease, negatively affects iron …