[HTML][HTML] The metabolic basis for nervous system dysfunction in alzheimer's disease, parkinson's disease, and huntington's disease

K Maiese - Current neurovascular research, 2023 - ncbi.nlm.nih.gov
Disorders of metabolism affect multiple systems throughout the body, but may have the
greatest impact on both central and peripheral nervous systems. Current available …

Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders

H Cai, W Cong, S Ji, S Rothman… - Current Alzheimer …, 2012 - ingentaconnect.com
Alzheimer's disease and other related neurodegenerative diseases are highly debilitating
disorders that affect millions of people worldwide. Efforts towards developing effective …

Neurodegenerative diseases–is metabolic deficiency the root cause?

VR Muddapu, SAP Dharshini… - Frontiers in …, 2020 - frontiersin.org
Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

Metabolic features of brain function with relevance to clinical features of Alzheimer and Parkinson diseases

DA Butterfield, M Favia, I Spera, A Campanella… - Molecules, 2022 - mdpi.com
Brain metabolism is comprised in Alzheimer's disease (AD) and Parkinson's disease (PD).
Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids …

Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders

TS McDonald, T Lerskiatiphanich… - Journal of Cerebral …, 2023 - journals.sagepub.com
Neurodegeneration refers to the selective and progressive loss-of-function and atrophy of
neurons, and is present in disorders such as Alzheimer's, Huntington's, and Parkinson's …

Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in neurodegenerative disease

K Maiese - International review of neurobiology, 2020 - Elsevier
Non-communicable diseases (NCDs) that involve neurodegenerative disorders and
metabolic disease impact over 400 million individuals globally. Interestingly, metabolic …

Metabolic dysfunction in Alzheimer's disease: from basic neurobiology to clinical approaches

JR Clarke, FC Ribeiro, RL Frozza… - Journal of …, 2018 - content.iospress.com
Clinical trials have extensively failed to find effective treatments for Alzheimer's disease (AD)
so far. Even after decades of AD research, there are still limited options for treating …

Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging

NRW Cleland, SI Al-Juboori, E Dobrinskikh… - Journal of …, 2021 - Springer
Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease
(PD) and multiple sclerosis (MS), are relatively common and devastating neurological …

Cellular metabolism: A fundamental component of degeneration in the nervous system

K Maiese - Biomolecules, 2023 - mdpi.com
It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

The triangle of death in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein …

F Di Domenico, E Barone, M Perluigi… - Antioxidants & redox …, 2017 - liebertpub.com
Significance: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder and
represents one of the most disabling conditions. AD shares many features in common with …