[HTML][HTML] “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
A Canciello, A Cerveró-Varona, A Peserico… - Frontiers in Cell and …, 2022 - frontiersin.org
Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically
interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an …
interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an …
Biophysical and biochemical attributes of hybrid epithelial/mesenchymal phenotypes
AR Subbalakshmi, B Ashraf, MK Jolly - Physical Biology, 2022 - iopscience.iop.org
The epithelial–mesenchymal transition (EMT) is a biological phenomenon associated with
explicit phenotypic and molecular changes in cellular traits. Unlike the earlier-held popular …
explicit phenotypic and molecular changes in cellular traits. Unlike the earlier-held popular …
[HTML][HTML] Emerging concepts of hybrid epithelial-to-mesenchymal transition in cancer progression
D Sinha, P Saha, A Samanta, A Bishayee - Biomolecules, 2020 - mdpi.com
Epithelial mesenchymal transition (EMT) is a complex process through which epithelial (E)
cells lose their adherens junctions, transform into mesenchymal (M) cells and attain motility …
cells lose their adherens junctions, transform into mesenchymal (M) cells and attain motility …
[HTML][HTML] Epithelial-to-mesenchymal transition in the light of plasticity and hybrid E/M states
L Bornes, G Belthier, J van Rheenen - Journal of clinical medicine, 2021 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a cellular program which leads to cells losing
epithelial features, including cell polarity, cell–cell adhesion and attachment to the basement …
epithelial features, including cell polarity, cell–cell adhesion and attachment to the basement …
[HTML][HTML] Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response
Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states
during epithelial–mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often …
during epithelial–mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often …
Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer
J Verstappe, G Berx - Seminars in Cancer Biology, 2023 - Elsevier
Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
[HTML][HTML] Generation of Stable Epithelial–Mesenchymal Hybrid Cancer Cells with Tumorigenic Potential
R Tedja, AB Alvero, A Fox, C Cardenas, M Pitruzzello… - Cancers, 2023 - mdpi.com
Simple Summary Cancer spreading into different organs, or cancer metastasis, remains the
major clinical problem in almost all cancer types. Cancer metastasis is known to be …
major clinical problem in almost all cancer types. Cancer metastasis is known to be …
Epithelial–mesenchymal plasticity in tumor immune evasion
RDZ Mullins, A Pal, TF Barrett, ME Heft Neal, SV Puram - Cancer research, 2022 - AACR
Epithelial–mesenchymal transition (EMT) is a fundamental process that occurs during
embryogenesis and tissue repair. However, EMT can be hijacked by malignant cells, where …
embryogenesis and tissue repair. However, EMT can be hijacked by malignant cells, where …
Measuring and modelling the epithelial-mesenchymal hybrid state in cancer: clinical implications
The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of
elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We …
elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We …