Purpose The main metabolic pathways of oxycodone, a potent opioid analgetic, are N-
demethylation (CYP3A4) to inactive noroxycodone and O-demethylation (CYP2D6) to active …

Abstract Background and Objective Oxycodone is a μ-opioid receptor agonist that is mainly
metabolized by hepatic cytochrome P450 (CYP) enzymes. Because CYP enzymes can be …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Oxycodone is an opioid analgesic
that is metabolized mainly in the liver by cytochrome P450 (CYP) 2D6 and 3A4 enzymes.• …

Background Oxycodone is metabolized in the liver by means of O‐demethylation to form
oxymorphone in a reaction catalyzed by the enzyme cytochrome P450 2D6 (CYP2D6). This …

Background In vitro experiments suggest that circulating metabolites of oxycodone are
opioid receptor agonists. Clinical and animal studies to date have failed to demonstrate a …

Background The aim of this study was to investigate the effects of the cytochrome P450 3A4
(CYP34A) inhibitor itraconazole on the pharmacokinetics and pharmacodynamics of orally …

Background and purpose: There is high interindividual variability in the activity of drug‐
metabolizing enzymes catalysing the oxidation of oxycodone [cytochrome P450 (CYP) 2D6 …

Objective: Oxycodone (OC) is an opioid which exerts its analgesic effect through µ-receptors
in the brain. It is metabolized through CYP450 enzymes and some of the metabolites show …

In recent years the use of the opioid oxycodone has increased markedly and replacing
morphine as the first-line choice of opioid in several countries. There are formulations for …

Global oxycodone consumption has increased sharply during the last two decades, and, in
2008, oxycodone consumption surpassed that of morphine. As oxycodone was synthesized …