The initial reports regarding a cytotoxic role of calcium ions were published over 30 years
ago. In neurons, calcium ions can gain entry into the cell through several mechanisms …

The key role of calcium ions in the function of excitable tissues was appreciated as early as
1882 by Sidney Ringer. Since then, a plethora of cellular functions have been found to …

An influx of extraceUular Ca e+, with subsequent cellular Ca e+ overload, can clearly cause
certain types of cell death, and has been hypothesized to be a primary etiological event m …

It is widely believed that calcium plays a primary role in the development of neuronal cell
injury in different pathological states of the brain. Disturbances of calcium homeostasis may …

When calcium homeostasis fails, as occurs in anoxia and other energy-deprived states, cell
viability is threatened. This is probably because such states are accompanied either by an …

Our understanding of calcium's role in cerebral ischemia continues to evolve from the initial
recognition that it may be harmful to the ischemic cell. A multitude of experiments have …

Excitotoxicity is thought to be a major mechanism contributing to neurodegeneration during
central nervous system ischemia, trauma, and other neurological disorders. Briefly, synaptic …

Over the past several decades, an overwhelming body of research has greatly expanded
our understanding of the mechanisms underlying excitotoxicity in brain ischemia as well as …

This paper reviews the role of calcium in the brain under physiological and pathological
conditions. Calcium is a ubiquitous first and second messenger, and a regulator of metabolic …

Role of calcium ion (Ca2+) in the functioning of neurons from their naive state to mature
state is of vital importance. It controls functions such as neuronal functioning, neuronal ATP …