Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers
SA Kuismanen, MT Holmberg, R Salovaara… - The American journal of …, 2000 - Elsevier
Microsatellite instability (MSI) is a hallmark of hereditary nonpolyposis colorectal cancer, and
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …
Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high‐level microsatellite instability
RAU Bevilacqua, AJG Simpson - International journal of cancer, 2000 - Wiley Online Library
Microsatellite instability (MSI) in tumors from patients with hereditary non‐polyposis
colorectal cancer (HNPCC) is caused by germline mutations in mismatch repair (MMR) …
colorectal cancer (HNPCC) is caused by germline mutations in mismatch repair (MMR) …
Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
G Deng, A Chen, J Hong, HS Chae, YS Kim - Cancer research, 1999 - AACR
Microsatellite instability (MSI) has been described in tumors from patients with hereditary
nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI …
nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI …
Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications
A Zaanan, K Meunier, F Sangar, JF Fléjou, F Praz - Cellular oncology, 2011 - Springer
Background Microsatellite instability (MSI) constitutes an important oncogenic molecular
pathway in colorectal cancer (CRC), representing approximately 15% of all colorectal …
pathway in colorectal cancer (CRC), representing approximately 15% of all colorectal …
Hypermethylation of the hMLH1 Promoter in Colon Cancer with Microsatellite Instability
JM Cunningham, ER Christensen, DJ Tester, CY Kim… - Cancer research, 1998 - AACR
Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colon cancer and in a subset of patients with …
from patients with hereditary nonpolyposis colon cancer and in a subset of patients with …
Microsatellite instability in colorectal carcinoma: The comparison of immunohistochemistry and molecular biology suggests a role for hMLH6 immunostaining
V Rigau, N Sebbagh, S Olschwang… - … of pathology & …, 2003 - meridian.allenpress.com
Abstract Context.—Microsatellite instability (MSI) due to defective mismatch repair (MMR)
genes has been reported in the majority of colorectal tumors from patients with hereditary …
genes has been reported in the majority of colorectal tumors from patients with hereditary …
The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers
DA Lawes, T Pearson, S Sengupta… - British journal of cancer, 2005 - nature.com
There is increased incidence of microsatellite instability (MSI) in patients who develop
multiple primary colorectal cancers (CRC), although the association with hereditary …
multiple primary colorectal cancers (CRC), although the association with hereditary …
Epigenetic phenotypes distinguish microsatellite-stable and-unstable colorectal cancers
SA Kuismanen, MT Holmberg… - Proceedings of the …, 1999 - National Acad Sciences
Aberrant DNA methylation is a common phenomenon in human cancer, but its patterns,
causes, and consequences are poorly defined. Promoter methylation of the DNA mismatch …
causes, and consequences are poorly defined. Promoter methylation of the DNA mismatch …
[HTML][HTML] Microsatellite instability and hMLH1 and hMSH2 expression analysis in familial and sporadic colorectal cancer
S Salahshor, K Koelble, C Rubio, A Lindblom - Laboratory investigation, 2001 - Elsevier
Immunohistochemical expression analysis of mismatch repair gene products has been
suggested for the prediction of hereditary nonpolyposis colorectal cancer (HNPCC) carrier …
suggested for the prediction of hereditary nonpolyposis colorectal cancer (HNPCC) carrier …
hMSH6 Alterations in Patients with Microsatellite Instability-Low Colorectal Cancer
YR Parc, KC Halling, L Wang, ER Christensen… - Cancer research, 2000 - AACR
Two microsatellite instability (MSI) phenotypes have been described in colorectal cancer
(CRC): MSI-H (instability at> 30% of the loci examined) and MSI-L (MSI at 1–30% of the loci …
(CRC): MSI-H (instability at> 30% of the loci examined) and MSI-L (MSI at 1–30% of the loci …