Rapid signaling of estrogen involves membrane estrogen receptors (ERs), including
membrane subpopulations of ERα and ERβ. In the mid-1990s, several laboratories …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

It has been 20 years that the G protein-coupled estrogen receptor (GPER) was cloned as the
orphan receptor GPR30 from multiple cellular sources, including vascular endothelial cells …

Estrogens play an important role in the regulation of normal physiology, aging and many
disease states. Although the nuclear estrogen receptors have classically been described to …

GPR30, now named GPER1 (G protein-coupled estrogen receptor1) or GPER here, was first
identified as an orphan 7-transmembrane G protein-coupled receptor by multiple …

Abstract Estrogens, predominantly 17β-estradiol, exert diverse effects throughout the body in
both normal and pathophysiology, during development and in reproductive, metabolic …

Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

In 2005, two groups independently discovered that the G protein-coupled receptor GPR30
binds estradiol in cultured cells and, in response, initiates intracellular signaling cascades …

Estrogen can elicit pleiotropic cellular responses via a diversity of estrogen receptors (ERs)—
mediated genomic and rapid non-genomic mechanisms. Unlike the genomic responses …

Estrogen mediate its biological effects through its association with estrogen receptors (ERs).
They also regulate the expression of a variety of genes involved in distinct physiological …