The glycine betaine role in neurodegenerative, cardiovascular, hepatic, and renal diseases: Insights into disease and dysfunction networks

JA Rosas-Rodríguez, EM Valenzuela-Soto - Life sciences, 2021 - Elsevier
Abstract Glycine betaine (N, N, N-trimethyl amine) is an osmolyte accumulated in cells that is
key for cell volume and turgor regulation, is the principal methyl donor in the methionine …

Glycine betaine rather than acting only as an osmolyte also plays a role as regulator in cellular metabolism

CG Figueroa-Soto, EM Valenzuela-Soto - Biochimie, 2018 - Elsevier
For many years, glycine betaine (GB) has been widely studied as an osmolyte in plants and
bacteria. In animal cells, GB is an osmolyte mainly in the kidneys, but in humans many …

[HTML][HTML] Betaine in inflammation: mechanistic aspects and applications

G Zhao, F He, C Wu, P Li, N Li, J Deng, G Zhu… - Frontiers in …, 2018 - frontiersin.org
Betaine is known as trimethylglycine and is widely distributed in animals, plants, and
microorganisms. Betaine is known to function physiologically as an important …

[HTML][HTML] Implications of trimethylamine N-oxide (TMAO) and betaine in human health: beyond being osmoprotective compounds

A Ilyas, YS Wijayasinghe, I Khan… - Frontiers in Molecular …, 2022 - frontiersin.org
Osmolytes are naturally occurring small molecular weight organic molecules, which are
accumulated in large amounts in all forms of life in order to maintain the stability of cellular …

[HTML][HTML] Beneficial effects of betaine: a comprehensive review

MK Arumugam, MC Paal, TM Donohue Jr, M Ganesan… - Biology, 2021 - mdpi.com
Simple Summary A large number of studies report that medicinal herbs and many food
ingredients protect against the development of liver disease because they possess …

Betaine—The dark knight of the brain

M Bhatt, A Di Iacovo, T Romanazzi… - Basic & Clinical …, 2023 - Wiley Online Library
The role of betaine in the liver and kidney has been well documented, even from the cellular
and molecular point of view. Despite literature reporting positive effects of betaine …

Short and long-term variation of plasma glycine betaine concentrations in humans

M Lever, PCM Sizeland, CM Frampton… - Clinical biochemistry, 2004 - Elsevier
Background: Glycine betaine is important in cell volume regulation and in remethylating
homocysteine, a vascular risk factor. Objective: We investigated changes in circulating …

Involvement of GAT2/BGT-1 in the preventive effects of betaine on cognitive impairment and brain oxidative stress in amyloid β peptide-injected mice

D Ibi, A Tsuchihashi, T Nomura, M Hiramatsu - European journal of …, 2019 - Elsevier
In the pathophysiology of Alzheimer's disease (AD), the deposition of amyloid β protein (Aβ)
is associated with oxidative stress, leading to cognitive impairment and neurodegeneration …

[HTML][HTML] Glycine metabolism and its alterations in obesity and metabolic diseases

A Alves, A Bassot, AL Bulteau, L Pirola, B Morio - Nutrients, 2019 - mdpi.com
Glycine is the proteinogenic amino-acid of lowest molecular weight, harboring a hydrogen
atom as a side-chain. In addition to being a building-block for proteins, glycine is also …

Multifarious beneficial effect of nonessential amino acid, glycine: a review

MA Razak, PS Begum, B Viswanath… - … medicine and cellular …, 2017 - Wiley Online Library
Glycine is most important and simple, nonessential amino acid in humans, animals, and
many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and …