Immune responses depend on the ability of leukocytes to move from the circulation into
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …

Leukocyte adhesion to the endothelial cells lining the vessel wall and the subsequent
migration of the leukocytes into the underlying tissue are key elements of both innate and …

Leukocyte extravasation from the blood across the endothelium is vital for the functioning of
the immune system. Our understanding of the early steps of this process has developed …

Leucocytes use sophisticated mechanisms to cross the endothelium lining the vasculature.
This is initiated by chemokine-and adhesion molecule-induced intracellular signalling that …

A critical function of the inflammatory response is delivery of leukocytes to a site of injury,
immune reaction or infection. Considerable information is available concerning the …

Inflammation and immune surveillance rely on the ability of leukocytes to leave the blood
stream and enter tissue. Cytokines and chemokines regulate expression and the activation …

Migration of leukocytes into tissue is a key element of innate and adaptive immunity. While
the capturing of leukocytes to the blood vessel wall is well understood, little is known about …

Under a variety of (patho) physiological conditions, leukocytes will leave the bloodstream by
crossing the endothelial monolayer that lines the vessels and migrate into the underlying …

Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …

As the primary physical barrier between blood and tissue compartments within the body,
blood vessel endothelial cells and integrity of the cell junctions connecting them must be …