[HTML][HTML] Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis
Temporal lobe studies in motor neuron disease overwhelmingly focus on white matter
alterations and cortical grey matter atrophy. Reports on amygdala involvement are …
alterations and cortical grey matter atrophy. Reports on amygdala involvement are …
[HTML][HTML] MRI data confirm the selective involvement of thalamic and amygdalar nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis
RH Chipika, WF Siah, SLH Shing, E Finegan… - Data in brief, 2020 - Elsevier
A standardised imaging protocol was implemented to evaluate disease burden in specific
thalamic and amygdalar nuclei in 133 carefully phenotyped and genotyped motor neuron …
thalamic and amygdalar nuclei in 133 carefully phenotyped and genotyped motor neuron …
Basal ganglia involvement in amyotrophic lateral sclerosis
Objectives: To characterize the nature and extent of basal ganglia involvement in
amyotrophic lateral sclerosis (ALS) genotypes in vivo. Methods: Forty-four healthy controls …
amyotrophic lateral sclerosis (ALS) genotypes in vivo. Methods: Forty-four healthy controls …
Basal ganglia pathology in ALS is associated with neuropsychological deficits
Objectives: To evaluate basal ganglia changes along the amyotrophic lateral sclerosis (ALS)–
ALS–frontotemporal dementia (FTD) continuum using multiple, complementary imaging …
ALS–frontotemporal dementia (FTD) continuum using multiple, complementary imaging …
Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker opportunities
Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …
management implications. The objective of this study is the longitudinal evaluation of a large …
Genotype-associated cerebellar profiles in ALS: focal cerebellar pathology and cerebro-cerebellar connectivity alterations
Objective Cerebellar disease burden and cerebro-cerebellar connectivity alterations are
poorly characterised in amyotrophic lateral sclerosis (ALS) despite the likely contribution of …
poorly characterised in amyotrophic lateral sclerosis (ALS) despite the likely contribution of …
Multiparametric MRI study of ALS stratified for the C9orf72 genotype
Objective: To describe the patterns of cortical and subcortical changes in amyotrophic lateral
sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center …
sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center …
Widespread structural brain involvement in ALS is not limited to the C9orf72 repeat expansion
HJ Westeneng, R Walhout, M Straathof… - Journal of Neurology …, 2016 - jnnp.bmj.com
Background In patients with a C9orf72 repeat expansion (C9+), a neuroimaging phenotype
with widespread structural cerebral changes has been found. We aimed to investigate the …
with widespread structural cerebral changes has been found. We aimed to investigate the …
Cortical atrophy in ALS is critically associated with neuropsychiatric and cognitive changes
Objective: To characterize the patterns of brain atrophy in patients with amyotrophic lateral
sclerosis (ALS) with and without cognitive and neuropsychiatric symptoms, in comparison to …
sclerosis (ALS) with and without cognitive and neuropsychiatric symptoms, in comparison to …
Tackling clinical heterogeneity across the amyotrophic lateral sclerosis–frontotemporal dementia spectrum using a transdiagnostic approach
The disease syndromes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia
(FTD) display considerable clinical, genetic and pathological overlap, yet mounting …
(FTD) display considerable clinical, genetic and pathological overlap, yet mounting …