Background The use of local anaesthetics (LAs) is usually associated with few adverse
effects, but local anaesthetic systemic toxicity (LAST) can result in serious harm and even …

Despite advances in clinical practice, local anaesthetic systemic toxicity continues to occur
with the therapeutic use of local anaesthesia. Patterns of presentation have evolved over …

Local anesthetics (LAs) are extensively used in clinical practice by both anesthesiologists
and non-anesthesiologists and are often associated with systemic toxicity. We hypothesize …

Local anaesthetics are widely used throughout medical practice. They are used to induce
anaesthesia and analgesia for surgical procedures and for pain management. Nowadays …

INTRODUCTION—Local anesthetics (LAs) are administered in practice by many clinicians,
including anesthesiologists, surgeons, emergency department providers, dentists, and …

Abstract Background: Local anesthetics (LAs) are widely used in medical practice. The
prevalence of LAs used has attracted attention with increasing reports of toxicity. To our …

Purpose Local anesthetics are used for procedures in various settings. Although
complications related to local anesthetic use is rare, adverse events do occur. A significant …

Local anesthetic systemic toxicity (LAST) is a life-threatening adverse event that may occur
after the administration of local anesthetic drugs through a variety of routes. Increasing use …

The “Daring Discourse” of Liu et al1 in this issue of Regional Anesthesia and Pain Medicine
is a worthy addition to recent estimates of the frequency of local anesthetic systemic toxicity …

Background Acute, systemic toxicity associated with the use local anesthetics (LAST) has
been recognized as an important clinical problem since their introduction into clinical …