A search for antiinflammatory therapies: Synthesis, in silico investigation of the mode of action, and in vitro analyses of new quinazolin‐2, 4‐dione derivatives targeting …
AH Abdelmonsef, MA Abdelhakeem… - Journal of …, 2022 - Wiley Online Library
Inflammation is the response of the body's immune system to harmful stimuli. The expression
of phosphodiesterase 4 enzyme (PDE4) was demonstrated in many inflammatory cells …
of phosphodiesterase 4 enzyme (PDE4) was demonstrated in many inflammatory cells …
Synthesis, docking and anti-inflammatory activity of triazole amine derivatives as potential phosphodiesterase-4 inhibitors
Background: Phosphodiesterase 4 (PDE4), is one of the members of PDE superfamily which
catalyzes the hydrolysis of cyclic adenosine monophosphate to adenosine monophosphate …
catalyzes the hydrolysis of cyclic adenosine monophosphate to adenosine monophosphate …
Synthesis, anti-inflammatory activity and docking studies of some newer 1, 3-thiazolidine-2, 4-dione derivatives as dual inhibitors of PDE4 and PDE7
Background: Phosphodiesterase 4 (PDE4) and phosphodiesterase 7 (PDE7), PDE
superfamily members, increase inflammatory processes in immunomodulatory as well as …
superfamily members, increase inflammatory processes in immunomodulatory as well as …
Design, synthesis, molecular docking, and molecular dynamic studies of novel quinazoline derivatives as phosphodiesterase 7 inhibitors
AA El-Malah, MM Gineinah, MT Khayat… - Frontiers in …, 2024 - frontiersin.org
Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)-specific PDE
that is expressed in immune and proinflammatory cells. In this work, we explore the …
that is expressed in immune and proinflammatory cells. In this work, we explore the …
[HTML][HTML] Design and synthesis of novel indole-quinoxaline hybrids to target phosphodiesterase 4 (PDE4)
BJ Luther, CS Rani, N Suresh, MVB Rao… - Arabian Journal of …, 2019 - Elsevier
A series of novel hybrid molecules were designed rationally by connecting an indole moiety
with a quinoxaline ring through a linker as potential inhibitors of PDE4. Their design was …
with a quinoxaline ring through a linker as potential inhibitors of PDE4. Their design was …
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as potential PDE4 inhibitors
G Song, D Zhao, D Hu, Y Li, H Jin, Z Cui - Bioorganic & Medicinal …, 2015 - Elsevier
The design, synthesis, and biological evaluation of new phosphodiesterase type 4 (PDE4)
inhibitors, which possessed 7-(cyclopentyloxy)-6-methoxy 1, 2, 3, 4-tetrahydroisoquinoline …
inhibitors, which possessed 7-(cyclopentyloxy)-6-methoxy 1, 2, 3, 4-tetrahydroisoquinoline …
[HTML][HTML] Structure-based design, synthesis, biological evaluation, and molecular docking of novel PDE10 inhibitors with antioxidant activities
J Li, JY Chen, YL Deng, Q Zhou, Y Wu, D Wu… - Frontiers in …, 2018 - frontiersin.org
Phosphodiesterase 10 is a promising target for the treatment of a series of central nervous
system (CNS) diseases. Imbalance between oxidative stress and antioxidant defense …
system (CNS) diseases. Imbalance between oxidative stress and antioxidant defense …
Triazole‐Pyridine Dicarbonitrile Targets Phosphodiesterase 4 to Induce Cytotoxicity in Lung Carcinoma Cells
HK Keerthy, S Mohan, Basappa… - Chemistry & …, 2019 - Wiley Online Library
Abstract Phosphodiesterase 4 (PDE4) is a key enzyme involved in the hydrolysis of cyclic
adenosine monophosphate (cAMP) and widely expressed in several types of cancers. The …
adenosine monophosphate (cAMP) and widely expressed in several types of cancers. The …
Structure-based design and structure-activity relationships of 1, 2, 3, 4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors
Y Liao, Y Guo, S Li, L Wang, Y Tang, T Li… - Bioorganic & Medicinal …, 2018 - Elsevier
This paper describes our medicinal chemistry efforts on 7-(cyclopentyloxy)-6-methoxy1, 2, 3,
4-tetrahydroisoquinoline scaffold: design, synthesis and biological evaluation using …
4-tetrahydroisoquinoline scaffold: design, synthesis and biological evaluation using …
Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors
AHM Hussein, AA Khames, ABA El-Adasy, AA Atalla… - RSC …, 2020 - pubs.rsc.org
A new series of 2-aminothiazole derivatives was designed and prepared as
phosphodiesterase type 5 (PDE5) regulators and COX-1/COX-2 inhibitors. The screening of …
phosphodiesterase type 5 (PDE5) regulators and COX-1/COX-2 inhibitors. The screening of …