Drug Class Review HMG-CoA Reductase Inhibitors (Statins) and Fixed-dose Combination
Products Containing a Statin Page 1 Drug Class Review HMG-CoA Reductase Inhibitors (Statins) …

Coronary heart disease (CHD) continues to be the leading cause of mortality and a
significant cause of morbidity among North Americans. In 1999, CHD claimed 529,659 lives …

Statins: the HMG CoA reductase inhibitors in perspective Page 1 Statins The HMG CoA
Reductase Inhibitors in Perspective HO HC Edited by HC H CH, Allan Gaw Christopher J …

Controlled clinical studies and clinical experience over many years have proven that
virtually all patients benefit from lipid-lowering therapy with statins, even those with normal …

During the last decade, the development of the HMG CoA reductase inhibitors, commonly
referred to as 'statins', has contributed greatly to cholesterol lowering therapy and …

The statins have proved to be some of the most potent therapies for reducing elevated low‐
density lipoprotein (LDL) cholesterol and lessening the risk of coronary heart disease (CHD) …

Statins effectively lower LDL-cholesterol and some members of this class have been shown
to reduce the risk of major cardiovascular events and total mortality in patients with or at risk …

Objectives: Describe the indications for HMG-CoA reductase inhibitors (statins). Identify
potential adverse events and contraindications to statin use. Outline the appropriate follow …

Hypercholesterolaemia is a chronic condition that often requires life-long treatment, making
the safety of lipid-lowering drugs a critical issue. 3-hydroxy-3-methylglutaryl coenzyme A …

Abstract The 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitors, or
statins, are a well‐tolerated, effective class of medications for the reduction of low‐density …