We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD)
properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is …

Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …

Objectives A better dosing strategy can improve clinical outcomes for patients. We sought to
compare the extended or continuous infusion with conventional intermittent infusion of …

Objective: Piperacillin-tazobactam is a commonly used antibiotic in critically ill patients;
however, controversy exists as to whether mortality in serious infections can be decreased …

Outcomes of extended infusion piperacillin/tazobactam for documented Gram-negative infections -
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Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …

In the present study 24 hospitalized patients requiring empirical antibiotic treatment were
randomly assigned to receive the β-lactam antibiotic/β-lactamase inhibitor combination …

The standard mode of administration of piperacillin treatment is by intermittent infusion.
However, continuous infusion may be advantageous as β-lactam antibiotics exhibit time …

Objectives We utilized the database of the Defining Antibiotic Levels in Intensive care unit
patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and …

Continuous infusion of β-lactam antibiotics has been widely promoted to optimise their time-
dependent activity. Increasing evidence is emerging suggesting potential benefits in patient …