Aims/hypothesis Although a family history of type 2 diabetes is a strong risk factor for the
disease, the factors mediating this excess risk are poorly understood. In the InterAct case …

Aims/hypothesis Studying gene–lifestyle interaction may help to identify lifestyle factors that
modify genetic susceptibility and uncover genetic loci exerting important subgroup effects …

Purpose: To evaluate the use of self-reported family medical history as a potential screening
tool to identify people at-risk for diabetes. Methods: The HealthStyles 2004 mail survey …

OBJECTIVE—We sought to test the association between stratified levels of familial risk of
diabetes and the prevalence of the disease in the US population. RESEARCH DESIGN AND …

Aims/hypothesis We aimed to investigate whether the impact of obesity and unfavourable
lifestyle on type 2 diabetes risk is accentuated by genetic predisposition. Methods We …

In this study, Wareham and colleagues quantified the combined effects of genetic and
lifestyle factors on risk of T2D in order to inform strategies for prevention. The authors found …

Background: Genome-wide association studies have identified novel type 2 diabetes loci,
each of which has a modest impact on risk. Objective: To examine the joint effects of several …

OBJECTIVE To evaluate to what extent the association between family history of diabetes
and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors …

Background Whether genetic susceptibility to type 2 diabetes is modified by a healthy
lifestyle among Chinese remains unknown. Objectives The aim of the study was to …

Abstract Background The UK Biobank study provides a unique opportunity to study the
causes and consequences of disease. We aimed to use the UK Biobank data to study the …