Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

S Nourshargh, PL Hordijk, M Sixt - Nature reviews Molecular cell …, 2010 - nature.com
The shuttling of leukocytes between the bloodstream and interstitial tissues involves different
locomotion strategies that are governed by locally presented soluble and cell-bound signals …

[HTML][HTML] Leukocyte migration into inflamed tissues

S Nourshargh, R Alon - Immunity, 2014 - cell.com
Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …

Migration of leukocytes through the vessel wall and beyond

R Yadav, KY Larbi, RE Young… - Thrombosis and …, 2003 - thieme-connect.com
The migration of leukocytes from the vascular lumen to sites of infection and/or injury in the
extravascular tissue involves a series of sequential and coordinated molecular and cellular …

Leukocyte migration in the interstitial space of non-lymphoid organs

W Weninger, M Biro, R Jain - Nature Reviews Immunology, 2014 - nature.com
Leukocyte migration through interstitial tissues is essential for mounting a successful
immune response. Interstitial motility is governed by a vast array of cell-intrinsic and cell …

[HTML][HTML] Endothelial signaling in paracellular and transcellular leukocyte transmigration

ES Wittchen - Frontiers in bioscience: a journal and virtual library, 2009 - ncbi.nlm.nih.gov
As the primary physical barrier between blood and tissue compartments within the body,
blood vessel endothelial cells and integrity of the cell junctions connecting them must be …

Transmigration through venular walls: a key regulator of leukocyte phenotype and function

S Nourshargh, FM Marelli-Berg - Trends in immunology, 2005 - cell.com
Leukocyte transmigration is a key event in host defense. As well as delivering leukocytes to
sites of inflammation, this response also has an important role in immunity by regulating the …

Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps

P Alcaide, S Auerbach, FW Luscinskas - Microcirculation, 2009 - Taylor & Francis
Leukocyte recruitment to tissues and organs is an essential component of host defense. The
molecular mechanisms controlling this process are complex and remain under active …

Signaling in leukocyte transendothelial migration

JD Van Buul, PL Hordijk - Arteriosclerosis, thrombosis, and …, 2004 - Am Heart Assoc
Under a variety of (patho) physiological conditions, leukocytes will leave the bloodstream by
crossing the endothelial monolayer that lines the vessels and migrate into the underlying …

Endothelial signalling events during leukocyte transmigration

PL Hordijk - The FEBS journal, 2006 - Wiley Online Library
The notion that it takes two to tango is certainly true for leukocyte transendothelial migration.
A growing pallet of leukocyte adhesion‐induced signaling events in endothelial cells have …

LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ

R Sumagin, H Prizant, E Lomakina… - The Journal of …, 2010 - journals.aai.org
To exit blood vessels, most (∼ 80%) of the lumenally adhered monocytes and neutrophils
crawl toward locations that support transmigration. Using intravital confocal microscopy of …