Introduction Tumor infiltrating lymphocytes may indicate an immune response to cancer
development, but their significance remains controversial in breast cancer. We conducted …

Breast carcinomas are often infiltrated by inflammatory cells, particularly macrophages and T
lymphocytes, but the significance of these cells remains unclear. One possible role of these …

Baker K, Lachapelle J, Zlobec I, Bismar TA, Terracciano L & Foulkes WD (2011)
Histopathology58, 1107–1116 Prognostic significance of CD8+ T lymphocytes in breast …

Background The prognostic effect of tumor infiltrating CD8+ cytotoxic lymphocytes (CTLs) in
breast cancer is controversial. We analyzed the association between CD8+ CTLs and …

Although the favourable role of T lymphocyte populations in different tumour types is
established, that of B cells is still a matter of debate and needs further clarification. The …

Increased levels of total tumor-infiltrating lymphocytes (TILs) are generally associated with
good prognosis in several breast cancer subtypes. Subtypes of TILs impact both tumor cells …

While breast cancer has not been considered a cancer amenable to immunotherapeutic
approaches, recent studies have demonstrated evidence of significant immune cell …

Breast Cancer (BC) can be classified using pathologic features, such as grade and tumor
size. It can be categorized based on the gene expression profile, which identifies the distinct …

Background Molecular subtypes of breast cancer and presence of tumor-infiltrating immune
cells have both been implicated as important predictive and prognostic factors for improved …

Background While lymph node metastasis is among the strongest predictors of disease-free
and overall survival for patients with breast cancer, the immunological nature of tumor …