[HTML][HTML] Anything but ordinary–emerging splicing mechanisms in eukaryotic gene regulation
NH Gehring, JY Roignant - Trends in Genetics, 2021 - cell.com
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …
expression. The identification of the actual splice sites and the proper removal of introns are …
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …
Splicing regulation: from a parts list of regulatory elements to an integrated splicing code
Z Wang, CB Burge - Rna, 2008 - rnajournal.cshlp.org
Alternative splicing of pre-mRNAs is a major contributor to both proteomic diversity and
control of gene expression levels. Splicing is tightly regulated in different tissues and …
control of gene expression levels. Splicing is tightly regulated in different tissues and …
[HTML][HTML] Epigenetics in alternative pre-mRNA splicing
Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …
Pre-mRNA splicing: where and when in the nucleus
Alternative splicing is a process to differentially link exon regions in a single precursor
mRNA to produce two or more different mature mRNAs, a strategy frequently used by higher …
mRNA to produce two or more different mature mRNAs, a strategy frequently used by higher …
Co-transcriptional regulation of alternative pre-mRNA splicing
S Shukla, S Oberdoerffer - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
While studies of alternative pre-mRNA splicing regulation have typically focused on RNA-
binding proteins and their target sequences within nascent message, it is becoming …
binding proteins and their target sequences within nascent message, it is becoming …
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
[HTML][HTML] Regulation of alternative splicing: more than just the ABCs
AE House, KW Lynch - Journal of Biological Chemistry, 2008 - ASBMB
Alternative pre-mRNA splicing, the differential inclusion or exclusion of portions of a nascent
transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous …
transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous …
More than a splicing code: integrating the role of RNA, chromatin and non-coding RNA in alternative splicing regulation
Large portions of the genome undergo alternative pre-mRNA splicing in often intricate
patterns. Alternative splicing regulation requires extensive control mechanisms since errors …
patterns. Alternative splicing regulation requires extensive control mechanisms since errors …
Exon and intron definition in pre‐mRNA splicing
One of the fundamental issues in RNA splicing research is represented by understanding
how the spliceosome can successfully define exons and introns in a huge variety of pre …
how the spliceosome can successfully define exons and introns in a huge variety of pre …