[HTML][HTML] Anything but ordinary–emerging splicing mechanisms in eukaryotic gene regulation

NH Gehring, JY Roignant - Trends in Genetics, 2021 - cell.com
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

M Chen, JL Manley - Nature reviews Molecular cell biology, 2009 - nature.com
Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

Splicing regulation: from a parts list of regulatory elements to an integrated splicing code

Z Wang, CB Burge - Rna, 2008 - rnajournal.cshlp.org
Alternative splicing of pre-mRNAs is a major contributor to both proteomic diversity and
control of gene expression levels. Splicing is tightly regulated in different tissues and …

[HTML][HTML] Epigenetics in alternative pre-mRNA splicing

RF Luco, M Allo, IE Schor, AR Kornblihtt, T Misteli - Cell, 2011 - cell.com
Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …

Pre-mRNA splicing: where and when in the nucleus

J Han, J Xiong, D Wang, XD Fu - Trends in cell biology, 2011 - cell.com
Alternative splicing is a process to differentially link exon regions in a single precursor
mRNA to produce two or more different mature mRNAs, a strategy frequently used by higher …

Co-transcriptional regulation of alternative pre-mRNA splicing

S Shukla, S Oberdoerffer - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
While studies of alternative pre-mRNA splicing regulation have typically focused on RNA-
binding proteins and their target sequences within nascent message, it is becoming …

Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects

ME Rogalska, C Vivori, J Valcárcel - Nature Reviews Genetics, 2023 - nature.com
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

[HTML][HTML] Regulation of alternative splicing: more than just the ABCs

AE House, KW Lynch - Journal of Biological Chemistry, 2008 - ASBMB
Alternative pre-mRNA splicing, the differential inclusion or exclusion of portions of a nascent
transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous …

More than a splicing code: integrating the role of RNA, chromatin and non-coding RNA in alternative splicing regulation

RF Luco, T Misteli - Current opinion in genetics & development, 2011 - Elsevier
Large portions of the genome undergo alternative pre-mRNA splicing in often intricate
patterns. Alternative splicing regulation requires extensive control mechanisms since errors …

Exon and intron definition in pre‐mRNA splicing

L De Conti, M Baralle, E Buratti - Wiley Interdisciplinary …, 2013 - Wiley Online Library
One of the fundamental issues in RNA splicing research is represented by understanding
how the spliceosome can successfully define exons and introns in a huge variety of pre …