Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: a [18F]-fluoro-2-deoxy-D-glucose PET/CT study

G Bellani, C Messa, L Guerra, E Spagnolli… - Critical care …, 2009 - journals.lww.com
Objective: Neutrophilic inflammation plays a key role in the pathogenesis of acute
respiratory distress syndrome (ARDS) and acute lung injury (ALI). Positron emission …

Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury

JB Borges, ELV Costa, F Suarez-Sipmann… - Critical care …, 2014 - journals.lww.com
Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …

Lung inhomogeneities, inflation and [18F] 2-fluoro-2-deoxy-D-glucose uptake rate in acute respiratory distress syndrome

M Cressoni, D Chiumello, C Chiurazzi… - European …, 2016 - Eur Respiratory Soc
The aim of the study was to determine the size and location of homogeneous
inflamed/noninflamed and inhomogeneous inflamed/noninflamed lung compartments and …

Positron emission tomography with [18F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury

DL Chen, DP Schuster - American Journal of Physiology …, 2004 - journals.physiology.org
We measured neutrophil glucose uptake with positron emission tomographic imaging and
[18F] fluorodeoxyglucose ([18F] FDG-PET) in anesthetized dogs after intravenous oleic acid …

Lung inflammation persists after 27 hours of protective Acute Respiratory Distress Syndrome Network Strategy and is concentrated in the nondependent lung

JB Borges, ELV Costa, M Bergquist… - Critical care …, 2015 - journals.lww.com
Objective: PET with [18 F] fluoro-2-deoxy-D-glucose can be used to image cellular
metabolism, which during lung inflammation mainly reflects neutrophil activity, allowing the …

Assessment of Lung Inflammation With 18F-FDG PET During Acute Lung Injury

N de Prost, MR Tucci, MFV Melo - American Journal of …, 2010 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this review is to describe the current experimental and clinical
data regarding the fundamentals and applications of 18F-FDG PET during acute lung injury …

Regional distribution of gas and tissue in acute respiratory distress syndrome. I. Consequences for lung morphology

L Puybasset, P Cluzel, P Gusman, P Grenier… - Intensive care …, 2000 - Springer
Objective: To compare the computed tomographic (CT) analysis of the distribution of gas
and tissue in the lungs of patients with ARDS with that in healthy volunteers. Design …

Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury

G Bellani, L Guerra, G Musch, A Zanella… - American journal of …, 2011 - atsjournals.org
Rationale: During acute lung injury (ALI), mechanical ventilation can aggravate inflammation
by promoting alveolar distension and cyclic recruitment–derecruitment. As an estimate of the …

18F-FDG kinetics parameters depend on the mechanism of injury in early experimental acute respiratory distress syndrome

N De Prost, Y Feng, T Wellman, MR Tucci… - Journal of Nuclear …, 2014 - Soc Nuclear Med
PET with 18F-FDG allows for noninvasive assessment of regional lung metabolism reflective
of neutrophilic inflammation. This study aimed at determining during early acute lung injury …

Comparison of static and dynamic 18F-FDG PET/CT for quantification of pulmonary inflammation in acute lung injury

A Braune, F Hofheinz, T Bluth, T Kiss… - Journal of Nuclear …, 2019 - Soc Nuclear Med
PET imaging with 18F-FDG followed by mathematic modeling of the pulmonary uptake rate
(Ki) is the gold standard for assessment of pulmonary inflammation in experimental studies …