Cyclooxygenases (Cox)-1 and-2 play important roles in gastrointestinal health; chronic
overexpression of Cox-2 is associated with inflammatory and cancerous disease, whereas …

Cyclo-oxygenase (COX) profile predicts prognosis of gastric cancer; COX-2 positive tumors
are more often aggressive, and COX-2 suppression is protective against gastric cancer. In …

Cyclooxygenase-2 (COX) 2 promotes intestinal wound healing but elicits also
proinflammatory effects and has been implicated in colorectal carcinogenesis. Thus, a …

Background & Aims: Evidence is accumulating that inhibitors of cyclooxygenase (COX)-2
activity are useful for preventing human colon cancer. Therefore, it is important to determine …

BACKGROUND Experimental, clinical, and epidemiological studies have implicated
mitogenic metabolites of arachidonic acid such as prostaglandin E2 (PGE2) in colorectal …

Factors related to diet and life style have been identified as primary determinants in about
80% of colorectal cancers. Non-steroidal anti-inflammatory drugs (NSAID) and selective …

Cyclooxygenase (COX) consists of two isozymes, COX-1 and COX-2. The roles of these
isozymes in the gastrointestinal tract are unknown. We investigated messenger RNA …

Epidemiological, clinical, animal and laboratory studies have all provided evidence for the
protective effects of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, against …

Abstract Cyclooxygenase-2 (COX-2), a key enzyme of prostanoid biosynthesis, plays an
important role in both hereditary and spontaneous colon cancer. Individuals with ulcerative …

COX-2 is overexpressed in gastric intestinal metaplasia, a precancerous condition. COX-2 is
overexpressed in early gastric cancer, in intestinal type but not diffuse type. There may be a …