Correct mitochondrial distribution is critical for satisfying local energy demands and calcium
buffering requirements and supporting key cellular processes. The mitochondrially targeted …

Defective mitochondrial distribution in neurons is proposed to cause ATP depletion and
calcium-buffering deficiencies that compromise cell function. However, it is unclear whether …

Neurons are highly polarised cells with an elaborate and diverse cytoarchitecture. But this
complex architecture presents a major problem: how to appropriately distribute metabolic …

It is fast emerging that maintaining mitochondrial function is important for regulating
astrocyte function, although the specific mechanisms that govern astrocyte mitochondrial …

Abstract Mitochondrial Rho GTPase 1 (Miro1) protein is a well-known adaptor for
mitochondrial transport and also regulates mitochondrial quality control and function …

Mitochondria are dynamically transported in and out of neuronal processes to maintain
neuronal excitability and synaptic function. In higher eukaryotes, the mitochondrial GTPase …

Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we
investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin …

Mitochondrial rho GTPase (Miro) is a mitochondrial outer membrane protein containing two
GTPase domains and two helix-loop-helix Ca2+-binding domains called EF hands …

In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐GTP ases regulate
mitochondrial transport along microtubules by linking mitochondria to kinesin and dynein …

Correct mitochondrial dynamics are essential to neuronal function. These dynamics include
mitochondrial trafficking and quality-control systems that maintain a precisely distributed and …