A high-fat diet (HFD) is linked with cytokines production by non-neuronal cells within the
hypothalamus, which mediates metabolic inflammation. These cytokines then activate …

The hypothalamus is a crucial organ for the maintenance of appropriate body fat storage.
Neurons in the hypothalamic arcuate nucleus (ARH) detect energy shortage or surplus via …

Obesity is believed to arise through the imbalance of energy homeostasis controlled by the
central nervous system, where the hypothalamus plays the fundamental role in energy …

The arcuate nucleus (ARC) of the hypothalamus plays a key role in sensing metabolic
feedback and regulating energy homeostasis. Recent studies revealed activation of …

Obesity is one of the worldwide prevalent disease caused by the imbalance between food
intake and energy expenditure. Over a 100 years of research demonstrate that …

Diet-induced obesity can lead to detrimental chronic disorders. The severity of this global
epidemic has encouraged ongoing research to characterize the mechanisms underlying …

Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in
peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the …

Diet-induced obesity leads to devastating and common chronic diseases, fueling ongoing
interest in determining new mechanisms underlying both obesity and its consequences. It is …

Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Background: Consumption of dietary fat is one of the key factors leading to obesity. High-fat
diet (HFD)-induced obesity is characterized by induction of inflammation in the …