The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis

L Mirabello, MA Clarke, CW Nelson, M Dean… - 2018 - mdpi.com
Of the~ 60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium,
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …

Human papillomavirus genomics: Understanding carcinogenicity

CW Nelson, L Mirabello - Tumour Virus Research, 2023 - Elsevier
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …

[HTML][HTML] HPV16 E7 genetic conservation is critical to carcinogenesis

L Mirabello, M Yeager, K Yu, GM Clifford, Y Xiao, B Zhu… - Cell, 2017 - cell.com
Although most cervical human papillomavirus type 16 (HPV16) infections become
undetectable within 1–2 years, persistent HPV16 causes half of all cervical cancers. We …

Genetic variations in human papillomavirus and cervical cancer outcomes

JS Rader, SW Tsaih, D Fullin… - … journal of cancer, 2019 - Wiley Online Library
Cervical cancer is driven by persistent infection of human papillomavirus (HPV), which is
influenced by HPV type and intratypic variants, yet the impact of HPV type and intratypic …

HPV16 sublineage associations with histology-specific cancer risk using HPV whole-genome sequences in 3200 women

L Mirabello, M Yeager, M Cullen… - JNCI: Journal of the …, 2016 - academic.oup.com
Background: HPV16 is a common sexually transmitted infection although few infections lead
to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only …

Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer …

R Jackson, BA Rosa, S Lameiras, S Cuninghame… - BMC genomics, 2016 - Springer
Abstract Background Human papillomaviruses (HPVs) are a worldwide burden as they are a
widespread group of tumour viruses in humans. Having a tropism for mucosal tissues, high …

Differential HPV16 variant distribution in squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma

S Nicolás‐Párraga, L Alemany… - … Journal of Cancer, 2017 - Wiley Online Library
Human Papillomavirus 16 (HPV16) causes 70% of invasive cervical cancers (ICC)
worldwide. Interaction between HPV16 genetic diversity, host genetics and target tissue …

Genetic predisposition to persistent human papillomavirus-infection and virus-induced cancers

H Espinoza, KT Ha, TT Pham, JL Espinoza - Microorganisms, 2021 - mdpi.com
Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens
worldwide and among the more than 200 identified HPV types, approximately 15 high risk …

[HTML][HTML] Deep sequencing of HPV16 genomes: A new high-throughput tool for exploring the carcinogenicity and natural history of HPV16 infection

M Cullen, JF Boland, M Schiffman, X Zhang… - Papillomavirus …, 2015 - Elsevier
For unknown reasons, there is huge variability in risk conferred by different HPV types and,
remarkably, strong differences even between closely related variant lineages within each …

Current updates on cancer-causing types of human papillomaviruses (HPVs) in East, Southeast, and South Asia

C Xia, S Li, T Long, Z Chen, PKS Chan, SS Boon - Cancers, 2021 - mdpi.com
Simple Summary Among the over 200 human papillomavirus (HPV) genotypes identified,
approximately 15 of them can cause human cancers. In this review, we provided an updated …