The follicle is the functional unit of the ovary, whereby ovarian development is largely
dependent on the development of the follicles themselves. The activation, growth, and …

Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …

The Hippo pathway has been associated with regulation of early follicle growth. Studies of
murine ovaries suggest that changes in the actin cytoskeleton, caused by fragmentation …

The ovary is an interesting organ that shows major structural changes within a short period
of time during each reproductive cycle. Follicle development is controlled by local paracrine …

Background: The Hippo signaling pathway, a highly conserved cell signaling system, exists
in most multicellular organisms and regulates cell proliferation, differentiation, and …

Primary ovarian insufficiency (POI) and polycystic ovarian syndrome are ovarian diseases
causing infertility. Although there is no effective treatment for POI, therapies for polycystic …

The Hippo signaling pathway, which is important in organ size regulation, is present in
organisms from the fly to mammals. Disruption of the Hippo signaling pathway leads to …

Clarifying the molecular mechanisms by which primordial follicles are initiated is crucial for
the prevention and treatment of female infertility and ovarian dysfunction. The Hippo …

Abstract Background The Hippo pathway plays critical roles in regulating cell proliferation,
differentiation and survival among species. Hippo pathway proteins are expressed in the …

Hippo signaling pathway consists of conserved serine/threonine kinases to maintain optimal
organ sizes. Studies have demonstrated that fragmentation of murine ovaries increases …