Abstract Regulatory CD4+ CD25+ T cells (Tregs) are defective numerically and functionally
in autoimmune hepatitis (AIH). We have investigated and compared the mechanism of …

BACKGROUND & AIMS: The pathogenesis of autoimmune hepatitis (AIH) is not understood,
but it was suggested that AIH may be related to a numerical or functional impairment of …

BACKGROUND & AIMS: Patients with autoimmune hepatitis (AIH) have reduced numbers
and function of CD4+ CD25highFOXP3+ T regulatory cells (Tregs). Tregs can be generated …

Abstract CD4+ CD25+ regulatory T cells (T‐regs) are central to the maintenance of immune
tolerance and represent an immune intervention candidate in autoimmune hepatitis (AIH), a …

There are three classic liver diseases with probable autoimmune etiology: primary biliary
cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. The occurrence of these …

Abstract CD4+ CD25+ regulatory T cells (Treg) are important mediators of peripheral
immune tolerance; however, whether Treg participate also in hepatic immune tolerance is …

Regulatory T cells (Tregs), which are characterized by expression of CD4, CD25, and
Foxp3, play a crucial role in the control of immune responses to both self and non-self Ags …

This study is aimed at examining the potential role of regulatory T‐(Treg‐) Th1‐Th17‐Th22
cells in the pathogenic process of autoimmune hepatitis (AIH). The numbers of Foxp3+ …

Abstract CD4+ CD25high regulatory T cells (Tregs) play a critical role in self‐tolerance, as
seen in murine autoimmunity. Studies on Tregs in human autoimmunity have focused …

Autoimmune hepatitis (AIH) is a severe and chronic liver disease, and its incidence has
increased worldwide in recent years. Research into the pathogenesis of AIH remains limited …