Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Congenital hyperinsulinism (CHI) is biochemically characterised by the dysregulated
secretion of insulin from pancreatic β-cells. It is a major cause of persistent …

Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin
release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe …

Congenital hyperinsulinism (CHI) is the result of unregulated insulin secretion from the
pancreatic β-cells leading to severe hypoglycaemia. In these patients it is important to make …

Congenital hyperinsulinism is characterised by the inappropriate release of insulin during
hypoglycaemia. This potentially life-threatening disorder can occur in isolation, or present as …

Under normal physiological conditions, pancreatic β-cells secrete insulin to maintain fasting
blood glucose levels in the range 3.5–5.5 mmol/L. In hyperinsulinemic hypoglycemia (HH) …

Context: Congenital hyperinsulinism (HI) is the most common cause of hypoglycemia in
children. The risk of permanent brain injury in infants with HI continues to be as high as 25 …

Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Hyperinsulinism is the single most common mechanism of hypoglycemia in neonates.
Dysregulated insulin secretion is responsible for the transient and prolonged forms of …

Insulin secretion from pancreatic β-cells is tightly regulated to keep fasting blood glucose
concentrations within the normal range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia …