[HTML][HTML] Aluminium bioaccumulation in colon cancer, impinging on epithelial-mesenchymal-transition and cell death

R Bonfiglio, R Sisto, S Casciardi, V Palumbo… - Science of The Total …, 2024 - Elsevier
We investigated the presence of aluminium (Al) in human colon cancer samples and its
potential association with biological processes involved in cancer progression, such as …

Metabolomic analysis reveals the mechanism of aluminum cytotoxicity in HT-29 cells

L Yu, J Wu, Q Zhai, F Tian, J Zhao, H Zhang, W Chen - PeerJ, 2019 - peerj.com
Background Aluminum (Al) is toxic to animals and humans. The most common sources of
human exposure to Al are food and beverages. The intestinal epithelium is the first barrier …

Effects of Aluminum on the Integrity of the Intestinal Epithelium: An in Vitro and in Vivo Study

CH Jeong, HC Kwon, DH Kim, WN Cheng… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Aluminum (Al) is the most abundant and ubiquitous metal in the environment.
The main route of human exposure to Al is through food and water intake. Although human …

Aluminum exposure promotes the metastatic proclivity of human colorectal cancer cells through matrix metalloproteinases and the TGF-β/Smad signaling pathway

CH Jeong, HC Kwon, WN Cheng, Y Choi… - Food and Chemical …, 2020 - Elsevier
Human exposure to aluminum (Al) mainly occurs through food intake. However, influences
of Al on the gastrointestinal tract have been rarely reported. In particular, the effect of Al on …

Toxicological consequences of experimental exposure to aluminum in human intestinal epithelial cells

M Djouina, N Esquerre, P Desreumaux, C Vignal… - Food and Chemical …, 2016 - Elsevier
Abstract Aluminum (Al), a non-essential element, is ubiquitous in industrialized societies.
Whereas adult intake is estimated between 3 and 12 mg/day according to dietary aluminum …

Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N6-Methyladenosine Modification of ATP13A3

S Li, S Xu, Y Chen, J Zhou, S Ben, M Guo… - Environmental …, 2023 - ACS Publications
Element contamination, including that from heavy metals, is associated with gastrointestinal
tumorigenesis, but the effects and mechanisms of crucial element exposure associated with …

Uptake and molecular impact of aluminum-containing nanomaterials on human intestinal caco-2 cells

H Sieg, C Braeuning, BM Kunz, H Daher… - …, 2018 - Taylor & Francis
Aluminum (Al) is one of the most common elements in the earth crust and increasingly used
in food, consumer products and packaging. Its hazard potential for humans is still not …

Aluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers

W Hao, C Hao, C Wu, Y Xu, C Jin - Chemosphere, 2022 - Elsevier
Aluminum is the most abundant metal element in the Earth's crust, which exists naturally in
the form of aluminum compounds. Aluminum is mainly absorbed through the gastrointestinal …

The meaning of aluminium exposure on human health and aluminium-related diseases

G Crisponi, D Fanni, C Gerosa, S Nemolato… - Biomolecular …, 2013 - degruyter.com
The aim of this review is to attempt to answer extremely important questions related to
aluminium-related diseases. Starting from an overview on the main sources of aluminium …

Gut: An underestimated target organ for Aluminum

C Vignal, P Desreumaux, M Body-Malapel - Morphologie, 2016 - Elsevier
Summary Since World War II, several factors such as an impressive industrial growth, an
enhanced environmental bioavailability and intensified food consumption have contributed …