Immune checkpoint blockade in infectious diseases
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …
[HTML][HTML] Anti-PD-1/PD-L1 therapy for infectious diseases: learning from the cancer paradigm
Objectives Immune checkpoint pathways regulate optimal host immune responses against
transformed cells, induce immunological memory, and limit tissue pathology. Conversely …
transformed cells, induce immunological memory, and limit tissue pathology. Conversely …
Immune checkpoints and their inhibition in cancer and infectious diseases
The development of chronic infections and cancer is facilitated by a variety of immune
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …
Immune checkpoint blockade: a common denominator approach to cancer therapy
The immune system recognizes and is poised to eliminate cancer but is held in check by
inhibitory receptors and ligands. These immune checkpoint pathways, which normally …
inhibitory receptors and ligands. These immune checkpoint pathways, which normally …
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets
HF Tsai, PN Hsu - Journal of biomedical science, 2017 - Springer
Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen
(CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses …
(CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses …
Current progress and future perspectives of immune checkpoint in cancer and infectious diseases
X Cai, H Zhan, Y Ye, J Yang, M Zhang, J Li… - Frontiers in …, 2021 - frontiersin.org
The inhibitory regulators, known as immune checkpoints, prevent overreaction of the
immune system, avoid normal tissue damage, and maintain immune homeostasis during the …
immune system, avoid normal tissue damage, and maintain immune homeostasis during the …
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy
CJ Nirschl, CG Drake - Clinical cancer research, 2013 - AACR
The expression of immune checkpoint molecules on T cells represents an important
mechanism that the immune system uses to regulate responses to self-proteins. Checkpoint …
mechanism that the immune system uses to regulate responses to self-proteins. Checkpoint …
Immune checkpoint blockade opens a new way to cancer immunotherapy
S Sadreddini, B Baradaran… - Journal of cellular …, 2019 - Wiley Online Library
Among the main promising systems to triggering therapeutic antitumor immunity is the
blockade of immune checkpoints. Immune checkpoint pathways regulate the control and …
blockade of immune checkpoints. Immune checkpoint pathways regulate the control and …
[HTML][HTML] Rethinking immune checkpoint blockade:'Beyond the T cell'
X Liu, GD Hogg, DG DeNardo - Journal for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
The clinical success of immune checkpoint inhibitors has highlighted the central role of the
immune system in cancer control. Immune checkpoint inhibitors can reinvigorate anti-cancer …
immune system in cancer control. Immune checkpoint inhibitors can reinvigorate anti-cancer …