Cancer is amenable to low-cost treatments, given that it has a significant metabolic
component, which can be affected through diet and lifestyle change at minimal cost. The …

Metabolic remodeling is a key feature of cancer development. Knowledge of cancer
metabolism has greatly expanded since the first observation of abnormal metabolism in …

Today still only 50% of newly diagnosed cancers can be cured. While molecular
mechanisms of cell proliferation are being studied intensively, comparably little research …

Otto Warburg's discovery in the 1920s that tumor cells took up more glucose and produced
more lactate than normal cells provided the first clues that cancer cells reprogrammed their …

Tumor metabolism is significantly altered to support the various metabolic needs of tumor
cells. The most prominent change is the increased tumor glycolysis that leads to increased …

Most tumors display oncogene-driven reprogramming of several metabolic pathways, which
are crucial to sustain their growth and proliferation. In recent years, both dietary and …

The way cancer cells utilize nutrients to support their growth and proliferation is determined
by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the …

The tumor microenvironment is a complex mix of cancerous and noncancerous cells
(especially immune cells and fibroblasts) with distinct metabolisms. These cells interact with …

The early observations by Dr Otto Warburg revealed that fundamentally metabolic
differences exist between malignant tumor cells and adjacent normal cells. Many studies …

Mortality from locally advanced and metastatic cancer remains high despite advances in our
understanding of the molecular basis of the disease and improved adjuvant therapies …