The relationship between exposure to general anesthetic agents and the risk of developing an impulse control disorder
L Xie, Y Hu, D Yan, P McQuillan, Y Liu, S Zhu… - Pharmacological …, 2021 - Elsevier
Most studies examining the effect of extended exposure to general anesthetic agents (GAAs)
have demonstrated that extended exposure induces both structural and functional changes …
have demonstrated that extended exposure induces both structural and functional changes …
Exposure to ketamine anesthesia affects rat impulsive behavior
A Melo, H Leite-Almeida, C Ferreira… - Frontiers in behavioral …, 2016 - frontiersin.org
Introduction: Ketamine is a general anesthetic (GA) that activates several neurotransmitter
pathways in various part of the brain. The acute effects as GA are the most well-known and …
pathways in various part of the brain. The acute effects as GA are the most well-known and …
Neonatal sevoflurane exposure induces impulsive behavioral deficit through disrupting excitatory neurons in the medial prefrontal cortex in mice
L Xie, Y Liu, Y Hu, B Wang, Z Zhu, Y Jiang… - Translational …, 2020 - nature.com
Sevoflurane, in particular multiple exposures, has been reported to cause the abnormal
neurological development including attention-deficit/hyperactivity disorder (ADHD). This …
neurological development including attention-deficit/hyperactivity disorder (ADHD). This …
General anesthesia as a factor affecting impulse activity and neuronal responses to putative neurotransmitters
F Windels, EA Kiyatkin - Brain research, 2006 - Elsevier
Although it is evident that general anesthesia should affect impulse activity and
neurochemical responses of central neurons, there are limited studies in which these …
neurochemical responses of central neurons, there are limited studies in which these …
Repeated isoflurane exposures impair long‐term potentiation and increase basal GABAergic activity in the basolateral amygdala
RP Long, V Aroniadou-Anderjaska, EM Prager… - Neural …, 2016 - Wiley Online Library
After surgery requiring general anesthesia, patients often experience emotional
disturbances, but it is unclear if this is due to anesthetic exposure. In the present study, we …
disturbances, but it is unclear if this is due to anesthetic exposure. In the present study, we …
General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity
JD Landin, M Palac, JM Carter, Y Dzumaga… - …, 2019 - Elsevier
Accumulating evidence indicates that exposure to general anesthetics during infancy and
childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and …
childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and …
Dual Actions of Volatile Anesthetics on GABAAIPSCs Dissociation of Blocking and Prolonging Effects
Background Volatile agents alter inhibitory postsynaptic currents (IPSCs) at clinically
relevant concentrations, an action that is thought to make an important contribution to their …
relevant concentrations, an action that is thought to make an important contribution to their …
Long-term effects of anesthesia on the brain: an update on neurotoxicity
R Rajendram, VB Patel, VR Preedy - Treatments, Mechanisms, and …, 2022 - Elsevier
Year on year millions of people receive anesthesia for a variety of reasons. The vast majority
of patients are apparently unharmed by the anesthetic agents. However, around the …
of patients are apparently unharmed by the anesthetic agents. However, around the …
Isoflurane modulates glutamatergic and GABAergic neurotransmission in the amygdala
A Ranft, J Kurz, M Deuringer… - European Journal of …, 2004 - Wiley Online Library
Attempts have been made to attribute the particular features of general anaesthesia such as
hypnosis, analgesia, amnesia and autonomic stability to certain brain regions. In the present …
hypnosis, analgesia, amnesia and autonomic stability to certain brain regions. In the present …
Is there any relationship between long-term behavior disturbance and early exposure to anesthesia?
RT Wilder - Current Opinion in Anesthesiology, 2010 - journals.lww.com
Although the evidence from animal studies is clear and continuing to mount that anesthetic
drugs given at the right time and in sufficiently high and prolonged doses do cause …
drugs given at the right time and in sufficiently high and prolonged doses do cause …