CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …
CCL13 and human diseases
L Li, F Dai, L Wang, Y Sun, L Mei, Y Ran… - Frontiers in …, 2023 - frontiersin.org
CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many
immune cells. Despite extensive research into its function in numerous disorders, a thorough …
immune cells. Despite extensive research into its function in numerous disorders, a thorough …
The roles of CCR9/CCL25 in inflammation and inflammation-associated diseases
X Wu, M Sun, Z Yang, C Lu, Q Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Chemokine is a structure-related protein with a relatively small molecular weight, which can
target cells to chemotaxis and promote inflammatory response. Inflammation plays an …
target cells to chemotaxis and promote inflammatory response. Inflammation plays an …
An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation? CCR6/CCL20: a chemokine axis balancing immunological …
Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence
suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key …
suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key …
CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?
Chemokines and their cognate receptors have been identified as major factors initiating and
governing cell movement and interaction. These ligands and their receptors are expressed …
governing cell movement and interaction. These ligands and their receptors are expressed …
The multiple faces of CCL13 in immunity and inflammation
E Mendez-Enriquez, EA García-Zepeda - Inflammopharmacology, 2013 - Springer
Abstract CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils,
basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable …
basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable …
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology.
Here, through a genome-wide association study of rheumatoid arthritis, we identified a …
Here, through a genome-wide association study of rheumatoid arthritis, we identified a …
[HTML][HTML] Dendritic cells and CCR7 expression: an important factor for autoimmune diseases, chronic inflammation, and cancer
EP Brandum, AS Jørgensen, MM Rosenkilde… - International journal of …, 2021 - mdpi.com
Chemotactic cytokines—chemokines—control immune cell migration in the process of
initiation and resolution of inflammatory conditions as part of the body's defense system …
initiation and resolution of inflammatory conditions as part of the body's defense system …
[HTML][HTML] CCL5/CCR5 axis in human diseases and related treatments
Z Zeng, T Lan, Y Wei, X Wei - Genes & diseases, 2022 - Elsevier
To defense harmful stimuli or maintain the immune homeostasis, the body produces and
recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among …
recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among …
CCR10 and its ligands in regulation of epithelial immunity and diseases
Epithelial tissues covering the external and internal surface of a body are constantly under
physical, chemical or biological assaults. To protect the epithelial tissues and maintain their …
physical, chemical or biological assaults. To protect the epithelial tissues and maintain their …
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