CCR6-CCL20 axis as a therapeutic target for autoimmune diseases

HT Meitei, N Jadhav, G Lal - Autoimmunity reviews, 2021 - Elsevier
Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …

CCL13 and human diseases

L Li, F Dai, L Wang, Y Sun, L Mei, Y Ran… - Frontiers in …, 2023 - frontiersin.org
CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many
immune cells. Despite extensive research into its function in numerous disorders, a thorough …

The roles of CCR9/CCL25 in inflammation and inflammation-associated diseases

X Wu, M Sun, Z Yang, C Lu, Q Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Chemokine is a structure-related protein with a relatively small molecular weight, which can
target cells to chemotaxis and promote inflammatory response. Inflammation plays an …

An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation? CCR6/CCL20: a chemokine axis balancing immunological …

I Comerford, M Bunting, K Fenix, S Haylock‐Jacobs… - …, 2010 - Wiley Online Library
Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence
suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key …

CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?

AYS Lee, R Eri, AB Lyons, MC Grimm… - Frontiers in …, 2013 - frontiersin.org
Chemokines and their cognate receptors have been identified as major factors initiating and
governing cell movement and interaction. These ligands and their receptors are expressed …

The multiple faces of CCL13 in immunity and inflammation

E Mendez-Enriquez, EA García-Zepeda - Inflammopharmacology, 2013 - Springer
Abstract CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils,
basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable …

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

Y Kochi, Y Okada, A Suzuki, K Ikari, C Terao… - Nature …, 2010 - nature.com
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology.
Here, through a genome-wide association study of rheumatoid arthritis, we identified a …

[HTML][HTML] Dendritic cells and CCR7 expression: an important factor for autoimmune diseases, chronic inflammation, and cancer

EP Brandum, AS Jørgensen, MM Rosenkilde… - International journal of …, 2021 - mdpi.com
Chemotactic cytokines—chemokines—control immune cell migration in the process of
initiation and resolution of inflammatory conditions as part of the body's defense system …

[HTML][HTML] CCL5/CCR5 axis in human diseases and related treatments

Z Zeng, T Lan, Y Wei, X Wei - Genes & diseases, 2022 - Elsevier
To defense harmful stimuli or maintain the immune homeostasis, the body produces and
recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among …

CCR10 and its ligands in regulation of epithelial immunity and diseases

N Xiong, Y Fu, S Hu, M Xia, J Yang - Protein & cell, 2012 - academic.oup.com
Epithelial tissues covering the external and internal surface of a body are constantly under
physical, chemical or biological assaults. To protect the epithelial tissues and maintain their …