Pregnanolone isomers (PIs) and their polar conjugates (PICs) modulate ionotropic receptors
such as γ-aminobutyric acid or pregnane X receptors. Besides, brain synthesis, PI …

Background: Pregnanolone isomers (PI) with a hydroxy group in the 3α-position are
neuroinhibitors operating via positive modulation of GABAA receptors. The 3β-PI and …

This study addresses the question of whether changes in the biosynthesis and metabolism
of neuroactive pregnanolone isomers (PIs) might participate in the timing of parturition in …

The levels of four pregnanolone isomers and their polar conjugates and pregnenolone
sulfate were measured in the plasma of 13 and 7 women at delivery with subarachnoidal …

The pregnanolone isomers (PI) allopregnanolone (3α-hydroxy-5α-pregnan-20-one),
pregnanolone (3α-hydroxy-5β-pregnan-20-one), isopregnanolone (3β-hydroxy-5α-pregnan …

Time profiles of the pregnanolone isomers epipregnanolone (3β-hydroxy-5β-pregnan-20-
one), allopregnanolone (3α-hydroxy-5α-pregnan-20-one), pregnanolone (3α-hydroxy-5β …

Progesterone and its 5α reduced metabolite, 5α-dihydroprogesterone, rise greatly in
pregnancy. Both are known to have anesthetic properties, as do a number of other ring A …

Allopregnanolone (ALLO) and pregnanolone (PREG), the 3α-reduced metabolites of
progesterone (PROG), are potent modulators of γ-aminobutyric acid type A receptors that …

A rapid method for the identification and measurement of four pregnanolone isomers and
their polar conjugates in human plasma was developed using a simple quadrupole GC/MS …

Neuroactive steroids are potent neuromodulators that play a critical role in both maternal
and fetal health during pregnancy. These stress-responsive compounds are reportedly low …